METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF ESOMEPRAZOLE IN TABLET DOSAGE FORM BY RP-HPLC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
A simple, precise, rapid, and accurate RP-HPLC method has been developed to determine esomeprazole magnesium trihydrate using chromatographic separation isocratically on C18 column (5 μm, 150mm x 4.60mm) and acetonitrile: water (HPLC grade) in the ratio of 50:50 (v/v) as the mobile phase, at a flow rate of 1ml/min. Detection was carried out at 289 nm. The retention times was found to be 5.6, the method was linear in the concentration range of 10-60μg/ml with R2=0.997 respectively. The proposed method is successfully applied for the determination of drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
Authors and Affiliations
C Parthiban , Divya swetha , V Pallavi , B Sowmya , Jeevani
Keywords
Related Articles
- EP ID EP108875
- DOI -
- Views 91
- Downloads 0
REDUCED PLASMA ANTIOXIDANT LEVELS IN SMOKING ASTHMATICS
The imbalance in antioxidants is thought to play an important role in the pathogenesis of bronchial asthma. The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in...
FORMULATION AND IN VITRO EVALUATION OF STOMACH SPECIFIC FLOATING MICROSPHERES OF SIMVASTATIN
The overall prevalence of dyslipidemia in India in 2013 was 10 % to 73 %. The prevalence of hyperlipidemia is more in females (33.2 %) than in males (32.4). On an average 32.8 % population is suffering from hyperlipidemi...
SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF IRBESARTAN AND HYDROCHLOROTHIAZIDE IN TABLETS
Two simple, sensitive, rapid, accurate and economic spectrophotometric methods were developed for the estimation of Irbesartan and Hydrochlorothiazide in two-component solid dosage form. First method is based on the simu...
FORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE MUCOADHESIVE BUCCAL TABLETS
The present study involves the formulation and evaluation of buccal tablets of venlafaxine hydrochloride, an antidepressant drug to circumvent the first pass metabolism. Buccal route is excellent for the systemic deliver...
PHYTOESTROGENS IN CANCERS AND SOME OTHER DISORDERS
Phytoestrogens are natural plant compounds which have a similarity to human estrogens. They hold great potential for health benefits. Recent epidemiological studies have suggested that typical Asian diets, which have alw...