METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF ESOMEPRAZOLE IN TABLET DOSAGE FORM BY RP-HPLC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
A simple, precise, rapid, and accurate RP-HPLC method has been developed to determine esomeprazole magnesium trihydrate using chromatographic separation isocratically on C18 column (5 μm, 150mm x 4.60mm) and acetonitrile: water (HPLC grade) in the ratio of 50:50 (v/v) as the mobile phase, at a flow rate of 1ml/min. Detection was carried out at 289 nm. The retention times was found to be 5.6, the method was linear in the concentration range of 10-60μg/ml with R2=0.997 respectively. The proposed method is successfully applied for the determination of drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
Authors and Affiliations
C Parthiban , Divya swetha , V Pallavi , B Sowmya , Jeevani
Keywords
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