Effect on the biochemical and hematological parameters on Rasa Mezhugu in Freund’s adjuvant-induced arthritis rats
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 10
Abstract
Rheumatoid Arthritis (RA) is a chronic, destructive inflammatory poly-articular joint and systemic autoimmune disease. It typically results in warm, swollen, and painful joints, stiffness often worsen following rest. The goal of treatment is to reduce pain, decrease inflammation, and improve a person's overall functioning. In spite of tremendous development in the field of synthetic drugs during recent years, the side effects could not be avoided. Hence the current research focus is to develop less toxic drugs as early as feasible in the disease process. A 90 day old Wistar male rat was used for the research and was divided in to four groups treated with Saline, Palm Jaggary, Rasa Mezhugu and Indomethacin. Evaluation of anti-arthritic potency, by body weight, biochemical and hematological analysis were analyzed. Rasa Mezhugu treatment rats have significantly reduces the Arthritis effect induced by complete Freund's adjuvant (CFA)-induced arthritic rat.
Authors and Affiliations
Dr. Nandhagopal K
Keywords
Related Articles
- EP ID EP203130
- DOI -
- Views 101
- Downloads 0
A Survey on the Knowledge, Attitude, and Practices about anti-biotic resistance among general practitioners of Northern India
The aim of the present study is to conduct a survey on the Knowledge, Attitude, and Practices about antimicrobial resistance among general practitioners of Northern India. This study was a questionnaire based cross secti...
An improved, scalable and robust process for the synthesis of cilastatin sodium: A renal dehydropeptidase inhibitor
An improved process developed for the synthesis of API, Cilastatin Sodium with more than 99.5% purity and all impurities well below the regulatory limits. The process was specially modified to control the epimeric impuri...
Assessment of knowledge, awareness and reporting of pharmacovigilance among the Nursing professionals
There is a considerable increase in awareness about the issues related to drug safety among the Nursing professionals, healthcare institutions and the public. Our aim of this present study was to assess the knowledge; aw...
RP-HPLC method development and validation for the simultaneous determination of lamivudine, abacavir and dolutegravir in pharmaceutical dosage forms
Abacavir is an antiretroviral drug used to treat HIV/AIDS. Lamivudine (2′,3′-dideoxy-3′-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). Dolutegravir (DTG) is an FD...
The application of peptide sequencing for characterization of cetrorelix and its related impurities
Electrospray ionization mass spectrometry (ESI-MS) was used to evaluate the structure of cetrorelix and the related impurities generated throughout the solid phase peptide synthesis (SPPS) reactions by Fmoc strategy. It...