EFFECTIVE HYPOGLYCEMIC ACTION OF METFORMIN COMBINATIONS AGAINST DEXAMETHASONE INDUCED DIABETES MELLITUS IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
Diabetes mellitus is a chronic metabolic disorder occurs due to the damage of β-cells of islets of Langerhans in pancreas. In general patients suffering for diabetes mellitus always use the medicines, apart from the medicines they take insulin also. In our study we did the preclinical experimental study of Metformin combinations on Albino Wistar rats such that which combination is effective for the patients who are using purposefully using the insulin. Our studies shown that Metformin + Glipizide shown the effective hypoglycemic results. For inducing diabetes mellitus we introduced Dexamethasone intraperitoneally as it is a steroidal anti-inflammatory agent and it is having hypoglycemic action as adverse effect.
Authors and Affiliations
Mohanraghupathy S, Jayabharath N, Bhuvana tejaY, Hameera khanam B, Lavanya lahari B
Keywords
Related Articles
- EP ID EP33065
- DOI -
- Views 288
- Downloads 0
ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF PLANT KALANCHOE PINNATA (LAM) PERS IN MICE
The main objective of present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate anti-diabetic activity of ethenolic and...
Development of new RP-HPLC method for the simultaneous estimation of Satranidazole and Oflaxacin pharmaceutical dosage form
A simple and selective LC method is described for the determination of Satranidazole and Ofloxacin in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixt...
Development and validation of UV Spectrophotometric method for the determination of Bamifylline hydrochloride in pharmaceutical dosage form
A simple, precise, cost effective, accurate UV- spectrophotometric method has been developed for the estimation of bamifylline hydrochloride in the Pharmaceutical dosage form. Bamifylline hydrochloride shows highest λm...
Development of antiasthmatic polyherbal formulation (triratna) as an alternative to synthetic steroidal formulation
In this study, methanolic leaves extract of Physalis angulata Linn (Solanaceae) (PAL), Adhatodavasaka Linn (Acanthaceae) (AVL) and Solanum nigrum Linn (Solanaceae) (SNL) and formulation (Triratna) of these three extrac...
Study on dried fruits properties using osmotic method and response surface methodology
Dehydration or osmotic drying is a process in which partial or all food water removes through putting it in a hypertonic solution of sugar or salt. In this study, in order to determine optimized condition of apple slice...