EFFECTIVE HYPOGLYCEMIC ACTION OF METFORMIN COMBINATIONS AGAINST DEXAMETHASONE INDUCED DIABETES MELLITUS IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
Diabetes mellitus is a chronic metabolic disorder occurs due to the damage of β-cells of islets of Langerhans in pancreas. In general patients suffering for diabetes mellitus always use the medicines, apart from the medicines they take insulin also. In our study we did the preclinical experimental study of Metformin combinations on Albino Wistar rats such that which combination is effective for the patients who are using purposefully using the insulin. Our studies shown that Metformin + Glipizide shown the effective hypoglycemic results. For inducing diabetes mellitus we introduced Dexamethasone intraperitoneally as it is a steroidal anti-inflammatory agent and it is having hypoglycemic action as adverse effect.
Authors and Affiliations
Mohanraghupathy S, Jayabharath N, Bhuvana tejaY, Hameera khanam B, Lavanya lahari B
Keywords
Related Articles
- EP ID EP33065
- DOI -
- Views 317
- Downloads 0
A Short Review on the Methods of Anthocyanin Determination
Term “anthocyanin” refers to the widest group of water soluble pigments response for red, blue and scarlet colors in fruits and vegetables. This article reviews different extraction and purification methods such as thi...
PREPARATION OF IMMEDIATE RELEASE ATORVASTATIN AND SUSTAINED RELEASE MATRIX TABLETS OF GLICLAZIDE USING RETARDANT: HYDROXYPROPYL METHYL CELLULOSE
In the present work an attempt has been made to formulate tablet containing immediate release Atorvastatin and sustained release Gliclazide using retardant namely hydroxypropyl methyl cellulose. Two different grade of...
EVALUATION OF ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF FLOWERS OF CASSIA SIAMEA IN ALLOXAN INDUCED DIABETIC RATS OF BASAL DIET AND MAIDA MIXED DIET
This study was carried out to evaluate the antihyperglycemic effect of the Methanol extracts of the flowers of C. siamea on alloxan induced rats of normal diet and maida mixed diet. The extracts were orally administered...
THE EFFECT OF SUPERDISINTEGRANTS ON THE DISSOLUTION OF CALCIUM CARBONATE FAST DISSOLVING TABLETS
The objective of the present study is to design and evaluate the effect of disintegrating agents such as Starch, Cross Caramellose Sodium, Sodium starch glycolate and crosprovidone Calcium carbonate conventional tablet...
Marketing Authorization Application (MAA) representation for preparation of DMF’s in European for active pharmaceutical ingredient
In this type of work a comparative study on marketing authorization application (MAA) representation for Preparation of Drug master files (DMF) in Europe for Active pharmaceutical ingredient (API) was reviewed thorough...