EFFECTIVE HYPOGLYCEMIC ACTION OF METFORMIN COMBINATIONS AGAINST DEXAMETHASONE INDUCED DIABETES MELLITUS IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
Diabetes mellitus is a chronic metabolic disorder occurs due to the damage of β-cells of islets of Langerhans in pancreas. In general patients suffering for diabetes mellitus always use the medicines, apart from the medicines they take insulin also. In our study we did the preclinical experimental study of Metformin combinations on Albino Wistar rats such that which combination is effective for the patients who are using purposefully using the insulin. Our studies shown that Metformin + Glipizide shown the effective hypoglycemic results. For inducing diabetes mellitus we introduced Dexamethasone intraperitoneally as it is a steroidal anti-inflammatory agent and it is having hypoglycemic action as adverse effect.
Authors and Affiliations
Mohanraghupathy S, Jayabharath N, Bhuvana tejaY, Hameera khanam B, Lavanya lahari B
Keywords
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- EP ID EP33065
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