EVALUATION OF ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF FLOWERS OF CASSIA SIAMEA IN ALLOXAN INDUCED DIABETIC RATS OF BASAL DIET AND MAIDA MIXED DIET
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
This study was carried out to evaluate the antihyperglycemic effect of the Methanol extracts of the flowers of C. siamea on alloxan induced rats of normal diet and maida mixed diet. The extracts were orally administered daily at 200 and 400 mg kg-1 body weight for three weeks. The effects of the extracts on Fasting Blood Glucose (FBG) level were determined weekly. All rats in the diabetic groups (both basal diet and maida mixed diet) had FBG levels well within the diabetic range (>150 mg dL-1) at the initial stage of the experiment but after three weeks of treatment with extracts or metformin. The FBG significantly dropped in dose-dependent manner, and also correct the lipid profile and liver enzymes. The results suggest that the Methanol extracts of the flowers of Cassia siamea restored the metabolic changes in alloxan-induced diabetic rats.
Authors and Affiliations
Pushpavathi P, Janarthan M, Firasat Ali
Keywords
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