Effective pH-responsive Hydrazine-Modified Silica for Doxorubicin Delivery
Journal Title: Asian Journal of Medicine and Health - Year 2017, Vol 4, Issue 1
Abstract
Aims: A type of pH-responsive porous nanosilica (PNS) for doxorubicin (DOX) delivery using Hydrazine was developed Study Design: PNS was first prepared by a sol-gel method and then modified with Hydrazine via 3-glycidoxypropyltrimethoxysilane (GPTMS) as coupling agents, (PNS-GPTMS-Hydrazine) for loading of DOX (DOX/PNS-GPTMS-Hydrazine). Place and Duration of Study: Department of Biomaterials & Bioengineering, Institute of Applied Materials Science, Vietnam Academy of Science and Technology, between February and June 2016. Methodology: The obtained PNS-GPTMS-Hydrazine were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). Moreover, DOX loading and release behavior of PNS-GPTMS-Hydrazine were also evaluated. Results: The PNS-GPTMS-Hydrazine was successfully synthesized with spherical shape and diameter range of 45-75 nm, which was a little larger than that of PNS-GPTMS of 35-65 nm. In addition, DOX was effectively encapsulated into PNS-GPTMS-Hydrazine nanoparticles, which was approximately 61.6%, and was slowly released up to 96 h in phosphate buffer saline (PBS, pH 7.4). Especially, the modified PNS was found to be rapidly release DOX under acidic environment (PBS, pH 5.5), indicating the pH-responsive property. Conclusion: These results demonstrated that PNS-GPTMS-Hydrazine can be used as an effective and pH-responsive nanocarriers for DOX delivery.
Authors and Affiliations
Uyen Vy Vo, Tuong Vi Tran, Do Minh Thien Nguyen, Cuu Khoa Nguyen, Ngoc Tram Nguyen Thi, Dai Hai Nguyen
Keywords
Related Articles
- EP ID EP336022
- DOI 10.9734/AJMAH/2017/32253
- Views 96
- Downloads 0
Unexpected Failure Events in Surgical Patients: Failure of the System or of the Patient?
Background: Unexpected failure events are undesired harmful effects, which result in prolonged hospital stay, higher mortality and morbidity rates and increased hospital costs. The aim of our study was to identify and th...
Assessment of Serum Electrolytes in Hypothyroid Patients Attending Chitwan Medical College Teaching Hospital
Aims: The aim of present study was to find out the serum concentration of two important electrolytes Sodium and Potassium in hypothyroid patients and establish its relationship with thyroid function parameters. Study Des...
Prevalence of Schistosomia haematobium and Staphylococcus aureus among Pregnant Women in Akure
Schistosomiasis is one of the most important parasitic disease of man. Staphylococcus aureus has also been observed as one of the causal agents of Urinary Tracts Infectionsand can be regarded as threat. This study focuse...
Naturally Available Essential Oils for Aromatherapy
Aromatherapy is an art of using essential oils for healing our mind and body. The meaning of aromatherapy is not so clear; the term ‘aroma’ means fragrance (sweet smell) and the term ‘therapy’ means to cure or to heal. A...
Investigation of Protamine Genes (PRM1, PRM2) Polymorphism and Its Impact on Sperm Toroid Integrity in Males from Ahmedabad (India)
Aim: Although infertility rates have been escalating in the past few years, there are very few studies directed towards its investigation, especially for males in the region of Ahmedabad, India. Hence the present study w...