Effectiveness of Artesunate and Mefloquine combination therapy in the treatment of uncomplicated Plasmodium falciparum Malaria in Eastern India: A cross sectional study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
BACKGROUND-Plasmodium falciparum(Pf) malaria is a major public health problem in India.Unfortunately, Pf has developed resistance to major antimalarial drugs,so malaria treatment moved in the era of Artemisinin Combination Therapy. AIMS - To evaluate the efficacy and tolerability of Artesunate and Mefloquine (AS+MQ) combination in uncomplicated Pf malaria in Kolkata,West Bengal. MATERIALS AND METHODSThe cross-sectional study was performed in the Malaria Clinic, School Of Tropical Medicine, Kolkata with 104 patients above 6 months of age.After a rapid screening procedure, patients fulfilling the inclusion criteria took part in the study. Peripheral blood smear,HRP2 Strip test were done for diagnosis. The participants were randomized to receive AS+ MQ. The study was done according to W.H.O PROTOCOL 2003 and appropriate follow up was performed. RESULTSData showed that mean fever clearance time was 2 days after initiating the drugs and mean parasite count also became zero by day2.Paired samples correlation of temperature was also significant.Kaplan Meier analysis showed that there was no treatment failure in the study arm. CONCLUSIONAS+MQ combination therapy is highly effective in the treatment of uncomplicated Pf malaria and the combination is also safe and tolerable.
Authors and Affiliations
Roy Sasmit, Maitra Somnath, Guha S. K, Maji A. K, Raychauduri Samik
Keywords
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- EP ID EP416641
- DOI 10.9790/0853-1711115966.
- Views 28
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