EFFECTIVENESS OF CONVENTIONAL VS. HYPO FRACTIONATED RT SCHEDULES FOR CHEST WALL IRRADIATION IN BREAST CANCER TREATMENT AND OUTCOME
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 2
Abstract
BACKGROUND Post mastectomy radiotherapy for patients with positive nodes derives a disease-free survival and overall survival benefit. Radiobiological models suggest that hypo fractionation might be equally effective for adjuvant RT in breast cancer. Evidence has been convincing, and this is now being accepted as standard practice. MATERIALS AND METHODS This retrospective cohort study compares the two fractionation schedules in Carcinoma Breast used in post mastectomy chest wall irradiation (50 Gy/25 fractions vs 40 Gy/ 15 fractions) regarding loco-regional control and toxicity profile. Patients were accrued from March 2011 to August 2013 and were followed up for a period of 1 year. A total of 195 patients were included in the study. RESULTS The baseline characteristics were similar in both arms. No statistically significant difference in disease free survival was seen between the two arms. The toxicity profile was also comparable. CONCLUSION After mastectomy for breast cancer, a radiotherapy schedule delivering 40 Gy in 15 fractions over 3 weeks seems to offer local regional tumour control and rates of normal tissue effects are at least as good as the accepted international standard of 50 Gy in 25 fractions over 5 weeks.
Authors and Affiliations
Suresh Kumar K, Kiran P, Joneetha Jones, Mintu Mathew, Snigdha P. P
Keywords
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- EP ID EP553064
- DOI 10.14260/jemds/2019/23
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