Effectiveness of Low Dose Rasburicase in Prevention and Treatment of Adult Tumour Lysis Syndrome: A Case Series Study
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2014, Vol 16, Issue 1
Abstract
Rasburicase, a recombinant urate oxidase product, is safe and effective in lowering serum uric acid. A schedule of rasburicase at a dose of 0.15-0.2 mg/kg given once daily intravenously for 5-7 days has been recommended in patients at risk of tumor lysis syndrome, but successful treatment with shorter duration of use has also been reported. The treatment is highly effective, but the cost of Rs 15,000 per 1.5 mg vial is very expensive. In year 2012 total four patients were treated with rasburicase at GCRI with a single dose of rasburicase prior to the initiation of chemotherapy, and the subsequent doses omitted as long as the serum urate levels remained below the upper limit of normal. Three of them died due to severe infection but there was drastic fall in serum uric acid even after single low dose of rasburicase, none requiring dialysis without any added drug related complication.
Authors and Affiliations
Vikas Gadhvi, Apurva Patel, Asha Anand, shailesh Talati, Sandip Shah, Harsha Panchal, Sonia Parikh
Keywords
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