Minimal Residual Disease Detection in Splenic Marginal Zone Lymphoma by Flow Cytometry and Cytogenetic Techniques
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 2
Abstract
Splenic marginal zone lymphoma (SMZL) is rare indolent B-cell lymphoma and affects elderly people. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Spleenectomy has been considered as the treatment of choice, however, it is a major surgical procedure with significant morbidity especially in elderly patients. It has been observed that after successful treatment SMZL cases do relapse. To detect residual disease in peripheral blood or bone marrow flowcytometric immunophenotyping and advanced cytogenetic techniques are considered to be sensitive enough. Here, we described minimal residual disease (MRD) detection in a case of SMZL.
Authors and Affiliations
Hemangini Vora, Birva Raiya, Pina Trivedi, Dharmesh Patel, Prabhudas Patel, Beena Brahmbhatt, Sonia Parikh
Keywords
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