Emerging Protumor Role of Gamma delta T Lymphocytes: Implications for Cancer Immunotherapy
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 1
Abstract
Cancer immunotherapy has recently achieved remarkable success in treating late stage tumors but a substantial fraction of patients failed to respond. A detailed understanding of how cellular and molecular interactions within the tumor micro environment sculpt the activities of innate and antigen specific immune cells is therefore important Tumorinfiltrating lymphocytes are key mediators of tumor immune surveillance and are important prognostic indicators in cancer progression. Among the various lymphocyte subsets implicated in protection against cancer are γδ T lymphocytes, which can kill tumor cells and secrete potent antitumor cytokines.
Authors and Affiliations
Shubhada Chiplunkar
Keywords
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