Effectiveness of prophylactic phenylephrine against placebo in prevention of post-sub arachnoid block hypotensive response in elective urological surgeries: A randomized double-blind controlled study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background: The most common complication of this anaesthetic technique is hypotension, with a particularly frequent incidence in the elderly. Various techniques are being used to control the hypotension. The main mechanical method is lower limb compression by elastic or pneumatic stocking or wrappings. Because of the poor efficacy of non-pharmacological technique in effectively managing hypotension – a vasopressor is almost always required. Aims and objectives: To study was the efficacy of IM phenylephrine against spinal anaesthesia-induced hypotension in normotensive patients scheduled for Elective Urological Surgeries. Materials and method: The present randomized controlled, double blind study was conducted in the department of anaesthesia of tertiary care institute to study complications after prophylactic phenylephrine and Placebo used for prevention of post Sub Arachnoid Block hypotensive response in patients undergoing elective urological surgeries under Sub Arachnoid Block”. Total 60 patients were enrolled in the present study and were divided in to two groups containing 30 patients each. A computer generated randomized plan was made, which placed patients randomly in the two groups. Group P (Phenylephrine group) and Group C (Control group). The collected data was recorded in excel sheet and was analysed with appropriate tests. A value of P<0.05 was considered statistically significant. Results: Both the groups were similar in age, ASA status, sex distribution and baseline hemodynamic variables. There was no significant difference in baseline SBP of both the groups. Fall in systolic blood pressure during 4-8min after sub- arachnoid block was observed. The fall in SBP observed in group C as compared to group P was significant which corresponds with the time taken to achieve required sensory dermatomal level. In 3.33% patient in group P while in 43.33% patients in group C and the difference observed statistically significant. Conclusion: In conclusion, we demonstrated that prophylactic injection of 2 mg of phenylephrine IM is a effective means for reducing the incidence of hypotension associated with hyperbaric bupivacaine spinal anaesthesia during elective urological surgeries in normotensive patients, including both young and elderly.
Authors and Affiliations
Meghna Maheshwari, Kashish Ahuja
Keywords
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- EP ID EP589647
- DOI 10.26611/10151021
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