Effectiveness of STOSS Therapy in Nutritional Rickets among Pediatric age Group in Bangladesh
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Background:Nutritional rickets resulting from vitamin D deficiency has become an increasing concern in both developed and developing countries. However, recommended treatment options are eithersmall doses dailysupplementation of vitamin D for few months or single-dayhigh-dose vitamin D, an approach referred to as stoss therapy. As fewer studies examine the effectiveness of this stoss therapy among Bangladeshi children; the study was designed so. Materials and Methods:The prospective, cross-sectional study was conducted in Dhaka Sishu (child) Hospital for 3-year period. Formal ethical clearance was taken prior commencement of the study. Total 50 child suffering from nutritional rickets were selected according to selection criteria. Written informed consent were taken from the parents of the child. Stoss therapy were administered under the guidance of the researcher. Before starting therapy base line clinical features and relevant investigation were recorded and it was compared with the value at 3 weeks, 3 months and 6 months follow up visit. Recoded data was analyzed by statistical software, SPSS 23 with 95% CI and acceptable 5% error. Results:Among the 50 rachitic child, mean age was 29.30±2.00 SD months (age range: 12-60 months). Median age was 26 months with 56% male and 44% female respondents. Following stoss therapy, significant clinical improvement was seen at 3 months and almost complete resolution of the most of the features over a period of 6 months. Significant improvement ofdifferent biochemical parameters (serum calcium, phosphate, ALP, and vitamin D) were seen and restored to almost normal level during 6 months therapy (p<.001). Radiological improvement was measured by Thacher’s 10 pointscale and significant improvement starts at 3 weeks which become completely normal at 6 months post therapy (p<.001). Conclusion:Stoss therapy can be a safe and effective measure for children of Bangladesh with Nutritional rickets.
Authors and Affiliations
Dr. Shahnaz Pervin Sumi, Dr. Md. Abu Tayab, Md. Jahangir Alam, Dr. A. AS. M. Nawshaduddin Ahmed, Dr. Md. Jahid Hasan, Dr. Md. Mahabubalam
Keywords
Related Articles
- EP ID EP369087
- DOI 10.9790/0853-1703050106.
- Views 51
- Downloads 0
Berlin’s Edema In Bundelkhand Region
Berlin’s edema following blunt ocular trauma,is a condition resulting from a countercoup mechanism, which can present with varying grades of visual impairment depending on the severity of the inciting injury. It is refer...
Epidemiology of Cervical Spinal Injuries in Government General Hospital, Kakinada, Andhra Pradesh.
Background; Currently there is no available information regarding the variety of cervical spine injury cases affected. Our study aim is to study the epidemiological prevalence of injuries, evaluation of management method...
Grading of Quality and Level of Adherence to the Care and Treatment among Clients Receiving of Antiretroviral Therapy Dessie Referral Hospital, South Wollo, Ethiopia
Background: Antiretroviral therapy (ART) is one of the interventions implemented to reduce morbidity and mortality due to HIV/AIDS. The evaluation of implementation process and its fidelity can give insight in to the “bl...
Clinical Trends of Pediatric Viral Infections- A Clinico Epidemiologic Study
Background: Cutaneous infections form an important component of pediatric dermatology. Pediatric viral infections are common and probably increasing in incidence over the last few decades because of increase in incidence...
Management of Open Apex in Permanent Teeth with Biodentine
Biodentine is new calcium silicate based cement that exhibits physical and chemical properties similar to those described for certain Portland cement derivatives. This article demonstrates the use of the newer material,...