Effectiveness of Systemic Administration of Amoxycillin and Metronidazole versus Azithromycin in Generalized Aggressive Periodontitis – A Randomized Controlled Clinical Trial
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 6
Abstract
Aim: To evaluate the effect of systemic Amoxycillin and Metronidazole against Azithromycin as an adjunct to non-surgical therapy and correlate the clinical periodontal parameters at baseline, 10 days and 30 days in subjects with generalized aggressive periodontitis (GAP). Study Design: Randomized controlled clinical trial. Place and Duration of the Study: The study was conducted in Saveetha Dental College and Hospitals from February 2015 to August 2015. Methods: Subjects were recruited from the outpatient department of Periodontics and were categorized as GAP according to AAP criteria. A total of 16 patients with GAP were included in the study. Clinical periodontal parameters like sulcus bleeding index [SBI], gingival index [GI], Probing depth [PD] and clinical attachment loss [CAL] were recorded at baseline. The subjects were then randomly allotted into Group 1 [Amoxycillin+Metronidazole] and Group II [Azithromycin]. After evaluation of clinical parameters at baseline, scaling and root planning [SRP] was done in both the Groups and systemic antibiotics, namely combination of Amoxycillin and Metronidazole in Group I and Azithromycin in Group II were administered. Subjects were recalled at day 10 and 30 for re-evaluation of clinical parameters. Within Group comparison was made using paired “t test” and inter Group comparison was made using Un-paired “t test”. Results: Intra-Group comparisons of clinical parameters between baseline and 30 days, in both the Groups were statistically significant (P<0.05). The difference from baseline to 30 days follow up in sulcus bleeding index (8.7±0.59 versus 4.1±0.38 mm) and clinical attachment loss (8.8±0.48 versus 4.6±0.39 mm) was statistically significant between the Groups (P<0.05). Whereas no statistical significance was found with gingival index and probing depth between the Groups (P>0.05). Conclusion: Systemic administration of Azithromycin as an adjunct to SRP in subjects with GAP resulted in better improvement of clinical periodontal parameters compared to a combination of Amoxycillin and Metronidazole.
Authors and Affiliations
Archana Mootha, Sankari Malaiappan, Sheeja S. Varghese, N. D. Jayakumar
Keywords
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- EP ID EP342400
- DOI 10.9734/BJPR/2016/22732
- Views 73
- Downloads 0
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