Effectiveness of Systemic Administration of Amoxycillin and Metronidazole versus Azithromycin in Generalized Aggressive Periodontitis – A Randomized Controlled Clinical Trial
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 6
Abstract
Aim: To evaluate the effect of systemic Amoxycillin and Metronidazole against Azithromycin as an adjunct to non-surgical therapy and correlate the clinical periodontal parameters at baseline, 10 days and 30 days in subjects with generalized aggressive periodontitis (GAP). Study Design: Randomized controlled clinical trial. Place and Duration of the Study: The study was conducted in Saveetha Dental College and Hospitals from February 2015 to August 2015. Methods: Subjects were recruited from the outpatient department of Periodontics and were categorized as GAP according to AAP criteria. A total of 16 patients with GAP were included in the study. Clinical periodontal parameters like sulcus bleeding index [SBI], gingival index [GI], Probing depth [PD] and clinical attachment loss [CAL] were recorded at baseline. The subjects were then randomly allotted into Group 1 [Amoxycillin+Metronidazole] and Group II [Azithromycin]. After evaluation of clinical parameters at baseline, scaling and root planning [SRP] was done in both the Groups and systemic antibiotics, namely combination of Amoxycillin and Metronidazole in Group I and Azithromycin in Group II were administered. Subjects were recalled at day 10 and 30 for re-evaluation of clinical parameters. Within Group comparison was made using paired “t test” and inter Group comparison was made using Un-paired “t test”. Results: Intra-Group comparisons of clinical parameters between baseline and 30 days, in both the Groups were statistically significant (P<0.05). The difference from baseline to 30 days follow up in sulcus bleeding index (8.7±0.59 versus 4.1±0.38 mm) and clinical attachment loss (8.8±0.48 versus 4.6±0.39 mm) was statistically significant between the Groups (P<0.05). Whereas no statistical significance was found with gingival index and probing depth between the Groups (P>0.05). Conclusion: Systemic administration of Azithromycin as an adjunct to SRP in subjects with GAP resulted in better improvement of clinical periodontal parameters compared to a combination of Amoxycillin and Metronidazole.
Authors and Affiliations
Archana Mootha, Sankari Malaiappan, Sheeja S. Varghese, N. D. Jayakumar
Keywords
Related Articles
- EP ID EP342400
- DOI 10.9734/BJPR/2016/22732
- Views 60
- Downloads 0
Evaluation of C. cassia Effectiveness in Behavioral Modulation of Haloperidol Induced Parkinson’s Disease (Mice Model)
Aims: This study was undertaken to evaluate the effectiveness of behavioral modulation of C. cassia extract against Haloperidol induced Parkinson’s disease (PD) in albino mice. Study Design: The study used...
Evaluation of Antibacterial Activity of Bryopsis pennata and Chaetomorpha antennina against Multidrug Resistant Morganella morganii and Salmonella species Isolated from Healthy Individuals
The problem of antibiotic resistance is fast becoming a pandemic which has necessitated the need for new drugs discovery. This study was carried out to screen two green algal species- Bryopsis pennata and Chaetomorpha an...
Anticancer Properties of Novel Rhenium Pentylcarbanato Compounds against MDA-MB-468(HTB-132) Triple Node Negative Human Breast Cancer Cell Lines
Aim: To study the efficacy of novel rhenium compounds to treat triple node negative breast cancer. Study Design: Six (6) novel rhenium pentycarbanato compounds (PC1-6) were synthesized and triple node negative breast can...
Study of Acid-base Indicator Property of Ethanolic Extract of Nerium indicum Flower
A study has been done to investigate the indicator property of ethanolic extract of Nerium indicum. The commonly used synthetics indicators cause environmental pollution and pose hazardous effects in human body. Natural...
Anesthesia Management in Rare Case: Osteogenesis Imperfecta
Osteogenesis imperfecta is a rare genetic disorder and a collagen tissue disease for which preoperative preparation and intra-operative anesthesia management must be performed with great care on patients. An operation wa...