Effects of activation of endocannabinoid system on myocardial metabolism
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Endocannabinoids exert their effect on the regulation of energy homeostasis via activation of specific receptors. They control food intake, secretion of insulin, lipids and glucose metabolism, lipid storage. Long chain fatty acids are the main myocardial energy substrate. However, the heart exerts enormous metabolic flexibility emphasized by its ability to utilzation not only fatty acids, but also glucose, lactate and ketone bodies. Endocannabinoids can directly act on the cardiomyocytes through the CB1 and CB2 receptors present in cardiomyocytes. It appears that direct activation of CB1 receptors promotes increased lipogenesis, pericardial steatosis and bioelectrical dysfunction of the heart. In contrast, stimulation of CB2 receptors exhibits cardioprotective properties, helping to maintain appropriate amount of ATP in cardiomyocytes. Furthermore, the effects of endocannabinoids at both the central nervous system and peripheral tissues, such as liver, pancreas, or adipose tissue, resulting indirectly in plasma availability of energy substrates and affects myocardial metabolism. To date, there is little evidence that describes effects of activation of the endocannabinoid system in the cardiovascular system under physiological conditions. In the present paper the impact of metabolic diseases, i. e. obesity and diabetes, as well as the cardiovascular diseases - hypertension, myocardial ischemia and myocardial infarction on the deregulation of the endocannabinoid system and its effect on the metabolism are described.
Authors and Affiliations
Agnieszka Polak, Ewa Harasim, Adrian Chabowski
Keywords
Related Articles
- EP ID EP220692
- DOI -
- Views 145
- Downloads 0
The role of immune system cells and their receptors in viral infections – selected data
The study of the immune system started about a hundred years ago with the phagocytosis experiments of Mechnikov. That which is now referred to as non-specific cell-mediated immunity was quickly linked to studies related...
Liposomy jako niewirusowe systemy dostarczania leków genetycznych
Metody leczenia chorób nowotworowych, zwłaszcza w ostatnich latach, dynamicznie się zmieniają, co wynika z potrzeby projektowania nowych, skuteczniejszych strategii terapeutycznych. Bardzo obiecująca w leczeniu chorób no...
Właściwości materiałowe więzadeł przyzębia
Chlamydiozy dróg moczowo-płciowych u ludzi
Chlamydie to bakterie występujące w środowisku człowieka, wywołujące wiele schorzeń. Zakażenia tymi bakteriami są powszechne zarówno wśród kobiet, jak i mężczyzn, choć częściej są diagnozowane u kobiet. Występują często...
Analiza modeli wektorowych w ocenie ilościowej artefaktów generowanych przez standardowe wkłady koronowo-korzeniowe w badaniu tomografii stożkowej (CBCT) – doniesienie wstępne