Effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular burns
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 10
Abstract
AIM: To investigate the effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular surface repair time, repair rate and complications in patients with ocular burns. <p>METHODS: The clinical data of each 61 cases(61 eyes)of patients with ocular burns who were treated by limbal stem cell autograft transplantation(control group)or amniotic membrane transplantation combined with limbal stem cell autograft transplantation(observation group)were retrospectively analyzed. The postoperative ocular surface repair rate, repair time, and visual acuity and complications(symblepharon, corneal neovascularization, and keratohelcosis)at 12wk after operation were recorded in the two groups, and the levels of cytokines \〖vascular endothelial growth factor(VEGF), transforming growth factor-β1(TGF-β1), insulin-like growth factor-1(IGF-1)\〗 were compared between the two groups before operation and at 2wk after operation. <p>RESULTS: The postoperative ocular surface repair rate in observation group was higher than that in control group(<i>P</i><0.05)while the repair time was less than that in control group(<i>P</i><0.05). At 12wk after operation, the visual acuity in observation group was significantly better than that in control group(<i>P</i><0.05), and the total incidence rate of postoperative complications in observation group was significantly lower than that in control group(<i>P</i><0.05). At 2wk after operation, the levels of serum VEGF, TGF-β1 and IGF-1 in the two groups were significantly higher than those before operation(<i>P</i><0.05), and the levels in control group were higher than those in observation group(<i>P</i><0.05). <p>CONCLUSION: Amniotic membrane transplantation combined with limbal stem cell autograft transplantation has significant treatment effects on patients with ocular burns, and it can promote ocular surface repair, improve postoperative visual acuity, and can also regulate corneal neovascularization, and it also has positive significance in reducing the risk of postoperative complications.
Authors and Affiliations
Guo-Ning Ye
Keywords
Related Articles
- EP ID EP547656
- DOI 10.3980/j.issn.1672-5123.2018.10.32
- Views 148
- Downloads 0
Protective effect of nerve growth factor combined with mecobalamine on optic nerve and influence on MMP-2 and TIMP-2
AIM: To investigate the protective effect of nerve growth factor(NGF)combined with mecobalamine on optic nerve and the influence on matrix metalloproteinase-2(MMP-2), tissue inhibitor of matrix metalloprotease-2(TIMP-2)....
Scleral buckling-induced ocular parameter changes in patients of rhegmatogenous retinal detachment
AIM: To evaluate the ocular parameter changes following scleral buckling(SB)for rhegmatogenous retinal detachment(RRD). <p>METHODS: This retrospective, non-randomized case-control study included 46 eyes of 23 patients wh...
Study of wavefront aberration in DR patients with different degree of dry eye
AIM: To compare the changes of wavefront aberrations in patients with diabetic retinopathy(DR)and with different degrees of dry eye and to explore the reasons of visual quality decline in them. <p>METHODS: We randomly se...
Roles of magnetic resonance imaging techniques in the study of eye disease
As magnetic resonance imaging(MRI)technology has the features of non-invasive, clear imaging, and high resolution to soft tissue, it has been used to both the clinic applications and basic researches of ophthalmic diseas...
Clinical analysis of SLE patients with retinopathy
AIM: To investigate the clinical characteristics of patients with systemic lupus erythematosus(SLE)complicated with retinopathy. <p>METHODS: Totally 121 cases of SLE patients treated in our hospital from February 2015 to...