Effects of Ampiclox andAmoxicillin on thePharmacokinetics of Metformin in Type II Diabetic Patients
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Infection is common in diabetes and in the course of treatment,ampiclox and amoxicillin may be coadministered with metformin. The study was designed to evaluate the effects of co-administration of ampiclox and amoxicillin on the pharmacokinetics of metformin in type II diabetic patients. Twelve patients with age ranging from 25 – 55 years, weight 50 – 70 kg and height 1.5 – 1.75 m participated in the study. The study was divided into two phases with a washout period of seven days between the phases. In phase one, metformin alone was administered to all the subjects with 150 ml of water after an overnight fasting. In phase two, the subjects were divided into two groups, with six subjects in each group. The first group received a single dose of metformin with ampiclox, while the second group received metformin co-administered with Amoxicillin. Blood samples were collected at 0, 0.5, 1.5, 3.0, 4.0, 6.0 and 8.0 hours post drug administration and stored at – 4 0C before analysis. Plasma was obtained from the blood and the drug was extracted from the plasma using three times its volume of acetonitrile. The samples were analyzed for metformin using a reversed phase HPLC method on a C–8column (4.6 x 150 nm), mobile phase acetonitrile/potassium dihydrogen orthophosphate (21:79) and a UV detector at 236 nm. When metformin was co-administered with ampiclox, Ka increased to 0.58 ±0.04hr-1 , Cmaxto 1.28 ±0.35 µg/ml, while AUC and t1/2β increased to 518.71 ±0.02 µg.h/ml and 6.2± 0.02hr respectively. These increments were found to be significant (p < 0.05). On the other hand, when metformin was coadministered with amoxicillin no significant changes (p <0.05) were observed.
Authors and Affiliations
Garba, M. A, 2Bakare- Odunola, Garba,M. , Yakasai, A. I, Musa, A. Haruna, A
Keywords
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