Effects of Centrally Applied Serotonin in Ventromedial Hypothalamic Nucleus on Regulation of Bile Secretion and Lipid Metabolism in the Rat
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2013, Vol 3, Issue 8
Abstract
Ventromedial hypothalamic nucleus (VMH) is one of the brain regions responsible for regulating gastrointestinal activities and lipid metabolism. Hepatic enzymes and serum lipids are controlled by the central nervous system and VMH is involved in the regulation of lipid metabolism. In the present study we sought to establish the role of serotonin to regulation of bile secretion, serum lipids level and hepatic enzymes in the rat. Rats were cannulated in the VMH for the administration of serotonin. After 1 week the common bile duct was cannulated and bile samples were collected after the administration of 5-HT, and biochemical analyses occurred on blood samples. Centrally applied 5-HT increased bile secretion at all studied periods and also decreased LDL-cholesterol (LDL-c) level. Present findings show that 5-HT participates in the central regulation of bile secretion in the rat, and VMH can be a special site for regulation of bile secretion and lipid levels.
Authors and Affiliations
J. Sajedianfard , M. Rahdar , S. Nazifi , F. A. Farsani
Keywords
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