Effects of Cinnamon Extract on Curing and Preventing Gentamicin-induced Nephrotoxicity in Immature White Rats
Journal Title: International journal of Advanced Biological and Biomedical Research - Year 2014, Vol 2, Issue 4
Abstract
Background and purpose: Gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ROS) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.Materials and methodology: in this study 36 immature female Wistar rats were divided into 6 equal groups. The control group did not receive any solution or medication. Every day The control group 1 received 200mg/kg hydro-alcoholic extract of cinnamon in Gavage form, the control group 2 received 80 mg/kg Gentimicin in intraperitoneal injection form, and empirical groups 1, 2 and 3 received 80 mg/kg Gentimicin in intraperitoneal injection form and 50, 100 and 200 mg Hydro-alcoholic extract of cinnamon in Gavage form for 14 days, respectively. Findings: Results show that serum concentrations of uric acid in sham group II increased significantly compared to the control group at 5%, and that the concentrations of urea and creatinine in sham group II and in the experimental group I were significantly higher compared to the control group at 1%. The diameter of proximal tubules in sham group II was significantly larger compared to the other groups (p<0.05). Furthermore, the diameter of glomeruli in the experimental groups and in sham group II significantly increased compared to the control group and sham group I. Conclusions: Cinnamon extracts have antioxidant properties and somewhat reduce the negative effects of Gentamicin. Therefore, it is recommended cinnamon extracts be used to reduce Gentamicin-induced nephrotoxicity in patients.
Authors and Affiliations
Sedigheh Tanomand| M.A. student, Islamic Azad University, Jahrom Branch, Department of Biology and Secretary of Education in Hormozgan, Iran, Nahid Alaeyan Jahromi| M.Sc, Department of agriculture, Shahrekord branch, Islamic Azad University, Shahrekord, Iran, Zahra Alaeyan Jahromi| M.Sc, Department of Biology, Jahrom branch, Islamic Azad University, Jahrom, Iran, Houshang Jamali| Assistant Professor, Department of Microbiology, Jahrom branch, Islamic Azad University, Jahrom, Iran, Majid Alaeyan Jahromi| M.Sc, Department of agriculture, Jahrom branch, Islamic Azad University, Jahrom, Iran, Ali Reza Alaeyan Jahromi| M.Sc, Department of Phytochemistry, Tehran branch, Payam Noor University, Tehran, Iran
Keywords
Related Articles
- EP ID EP13139
- DOI -
- Views 325
- Downloads 11
Thermodynamic characterization of the aggregation phenomena of SafranineT by spectral titration and chemometric analysis
The dimerization constants of Safranine T have been determined by studying the dependence of its absorption spectra on the temperature in the range 30ñ70 ◦C at different total concentrations of Safranine T (1.03×10...
Effect of plant growth regulators on rooting of henna (Lawsonia inermis L.)
Studies have shown that rooting substrate is one of the effective factors at rooting of hard rhizogenetic plant such as Henna. The purpose of this study is to determine an appropriate concentration of Naphthalene Aceti...
Evaluation of Different Amounts of Pelleted Manure with Urea and Micro Elements on Yield and Seed Quality of Medicinal Plant, Pumpkin (Cucurbita Pepo Var.Styriaca)
Objective: In this study investigated effects of different amounts of pelleted manure with urea and micro elements on yield and seed quality of medicinal plants, pumpkin (Cucurbita pepo var. styriaca). Methods: The ani...
A review on EEG based brain computer interface systems feature extraction methods
The brain – computer interface (BCI) provides a communicational channel between human and machine. Most of these systems are based on brain activities. Brain Computer-Interfacing is a methodology that provides a way...
The Effect of floodingand nutrition levels on reproductive growth stages of aerenchyma formation and ethylene production in soybean (Glycine max L)
To survey the effects of flooding during the reproductive growth stages of aerenchyma formation and ethylene production in soybean cultivar DPX experiment the completely randomized factorial was in 2012 in Gorgan Unive...