Effects of co-administration of fluoxetine and risperidone on properties of peritoneal and pleural macrophages in rats subjected to the forced swimming test.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
Literature data show that administration of atypical antipsychotic drug, risperidone (RIS), enhances antidepressive action of fluoxetine (FLU). As antidepressive treatments also regulate immune functions, we examined whether combined administration of FLU and RIS to rats subsequently subjected to a forced swimming test (FST) modifies parameters of macrophage activity that are directly related to their immunomodulatory functions, i.e., arginase (ARG) activity and nitric oxide (NO) synthesis.
Authors and Affiliations
Adam Roman, Justyna Kuśmierczyk, Ewa Klimek, Zofia Rogóż, Irena Nalepa
Keywords
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- EP ID EP135731
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