Effects of general anesthetics on the cognitive function of pediatric patients: A review
Journal Title: Perioperative Precision Medicine - Year 2023, Vol 1, Issue 3
Abstract
The consequences induced by the use of general anesthetics and better options of the drugs in children and infants have been topics of controversy due to the concerns about their potential impact on cognitive function. To address these concerns and ensure the safety of pediatric general anesthesia, this paper reviews existing basic and clinical studies that have investigated the mechanisms of general anesthetics on pediatric cognitive function. In this paper, the basic research on neurotoxicity of general anesthetics and the clinical research on the effects of general anesthesia drugs on cognitive function in children in recent years were analyzed and summarized. Although some of the clinical studies have suggested that general anesthesia in children or infants may cause neurocognitive damage and a series of behavioral complications, the results of the retrospective studies need to be viewed with caution as they may lack effective control for relevant factors that could have impacts in the perioperative period. It remains uncertain whether general anesthetics affect the cognitive function of pediatric patients. Further research is needed to establish clear evidence-based recommendations for clinical prevention and treatment measures to minimize the potential risks associated with the use of general anesthetics.
Authors and Affiliations
Yunfei Hao, Haoyan Lou, Jingnuo Jiang, Wenhui Guo, Zhanheng Chen, Bing Xu
Progress in heatstroke-induced multiple organ damage
Heatstroke is a life-threatening acute condition characterized by dysregulated temperature control, resulting in high core temperature and multi-organ dysfunction. Despite extensive research, the molecular mechanisms und...
Ultrasound-guided forearm selective nerve block: A bright future on the horizon
Objective: In light of the advancement of modern medicine, anesthesiologists and surgeons are increasingly prioritizing patient comfort in diagnostic and therapeutic procedures. A growing body of research revolves around...
Research progress of oxidative stress in sepsis-associated liver injury
Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment...
Progress of artificial intelligence in anesthesia and perioperative medicine
Perioperative medicine is a series of medical activities throughout the perioperative period, including preoperative optimization, intraoperative safety, postoperative rehabilitation, and other activities. Anesthesia is...
MicroRNAs: Regulators of the host antifungal immune response
Fungi pose a severe threat to human health worldwide, especially to patients with weakened immune systems. Perioperative patients are at a high risk of fungal infection and death because of the immunosuppression caused b...