Effects of gestational exercise on hyperoxia-induced brain damage in the newborn

Journal Title: UNKNOWN - Year 2018, Vol 1, Issue 4

Abstract

Aim: Preterm infants encounter hyperoxia relatively early on as they leave the intrauterine environment earlier than expected, while also being exposed to a higher level of hyperoxic stress due to insufficiencies in their antioxidant defense mechanisms. With that in mind, we investigate whether running exercises performed during pregnancy can contribute to the development of tolerance to neonatal hyperoxic brain damage. Method: While two female rats maintained a sedentary pregnancy, one female rat performed the mandatory running exercise for 30 minutes for five days a week throughout the pregnancy. Following delivery, the sedentary rats and the exercised rat were kept together with their offspring for five days at oxygen concentrations above 80 percent in order to induce brain damage. The offspring were sacrificed on postnatal Day 7 and brain/body ratio measurements were obtained. Results: The brain/body ratios in the control, hyperoxia and exercise-hyperoxia groups were found to be median (IQR) 0.074(0.68-0.77), 0.065(0.06-0.067) and 0.064(0.060-0.068), respectively. The brain/body ratios of the offspring of the mothers in the hyperoxia group were found to be significantly lower than the control group (p=0.002), irrespective of exercise (p=0.007). No statistically significant difference was noted between the offspring of the sedentary and the exercised mothers in the hyperoxia group (p=0.94). Conclusion: Hyperoxia was found to result in lower brain mass relative to total body mass. This finding, which indicates the presence of microcephaly, reflects the negative effects of hyperoxia on brain development. Contrary to expectations, exercises performed during pregnancy had no significant effect on the brain/body weight ratio of the offspring.

Authors and Affiliations

Mustafa Dilek, Gokce Kaya Dincel, Ayhan Cetinkaya, Gamze Dilek, Mervan Bekdas, Erol Ayaz, Nimet Kabakus

Keywords

Related Articles

Use of salidroside in a lipopolysaccharide-induced periventricular leukomalacia model

Aim: Research into the different treatment methods based on the intrauterine lipopolysaccharide (LPS)-induced periventricular leukomalacia (PVL) model, as one of the main causes of morbidity in preterm infants still cont...

Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats

Aim: Tadalafil is a potent, selective and reversible inhibitor of phosphodiesterase type 5 (PDE5) enzyme breakdowning cyclic guanosine monophosphate (cGMP). In this study, we aimed to investigate the effects of tadalafil...

The protective effects of ursodeoxycholic acid and the selective cyclooxygenase-2 inhibitor celecoxib on liver damage in an experimental cholestasis model

Aim: Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Ursodeoxycholic acid (UDCA) is the only Food and Drug Administration-approved treatment for cholestatic disorders...

Migralepsy; clinical and electroencephalography findings in children

Aim: Migralepsy is a clinical entity that occasionally represents a diagnostic problem. An apparent history and clinical manifestation of migraine may mask the epileptic attack accompanying migralepsy. The aim of this st...

Patients’ misperception regarding the difficulty of lumbar puncture

Aim: Lumbar puncture (LP) is a crucial method of diagnosis and treatment of neurological diseases. Despite its importance, the patients' refusal of the procedure leads to difficulties in diagnosis and treatment. One of t...

Download PDF file
  • EP ID EP489332
  • DOI 10.30714/j-ebr.2018443414
  • Views 190
  • Downloads 0

How To Cite

Mustafa Dilek, Gokce Kaya Dincel, Ayhan Cetinkaya, Gamze Dilek, Mervan Bekdas, Erol Ayaz, Nimet Kabakus (2018). Effects of gestational exercise on hyperoxia-induced brain damage in the newborn. UNKNOWN, 1(4), 123-127. https://europub.co.uk/articles/-A-489332