Effects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate antianxiety property of Lactuca sativa, an important and commonly used leafy vegetable known for its medicinal properties belongs to Asteraceae family. Methods: Elevated plus maze (EPM), open field test (OFT), rat exposure test, hyponeophagia and marble burying test were performed in mice models to assess the exploratory behaviour and to assess anxiolytic property of hydro-alcohol extract of Lactuca sativa. Diazepam (1 mg/kg body wt.) served as the standard anxiolytic agent for all the tests. The dried extract of the plant leaf in doses of 100, 200 and 400 mg/kg body weight was administered orally to mice for duration of 15 or 30 days and evaluated exploratory behaviour, locomotor and anxiolytic activities. Results: Time spent and number of entries into the open arm was measured in EPM followed by total locomotor activity in OFT and latency to enter the food zone in hyponeophagia. Conclusions: The study suggested that hydro-alcohol extract of Lactuca sativa leaves possess potent anxiolytic property
Pharmacognostic standardization and HPTLC analysis of the leaves of Hiptage benghalensis (L.) Kurz
Objective: To analyze the anatomical features, physiochemical characteristics and to carry out a high performance thin layer chromatography finger printing on the leaves of Hiptage benghalensis. Methods: Anatomical chara...
First detection on prevalence of Anaplasma marginale in sheep and goat in Karak District, Pakistan
Objective: To evaluate prevalence of Anaplasma marginale (A. marginale) and associated risk factors in sheep and goat. Methods: A total of 500 blood samples (250 from sheep and 250 from goat) were collected from three di...
Microscopic evaluation and physicochemical analysis of Origanum majorana Linn leaves
Objective: To study the microscopic evaluation and physicochemical analysis of Origanum majorana Linn leaves. Methods: Fresh and dried powdered leaf samples was studies for its morphology, microscopy, organoleptic charac...
Anisakis simplex (Nematoda: Anisakidae) from horse mackerel (Trachurus trachurus) in Atlantic coast of Morocco
Objective: To focus on the description of the Anisakis simplex (A. simplex) parasites of Trachurus trachurus (Linnaeus, 1758) from the Atlantic coast of Mehdia (Kenitra, Morocco) from December 2014 to November 2015. Meth...
Molecular typing of Mycobacterium tuberculosis isolates from Yaound é reveals RIF resistance markers, clonal relatedness and mutation patterns
Objective: To understand the spread of drug resistance and identifying diagnostic probes among the local tuberculosis (TB) strains in order to design rational control tools for tuberculosis controls. Methods: TA cloning...