Effects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To evaluate antianxiety property of Lactuca sativa, an important and commonly used leafy vegetable known for its medicinal properties belongs to Asteraceae family. Methods: Elevated plus maze (EPM), open field test (OFT), rat exposure test, hyponeophagia and marble burying test were performed in mice models to assess the exploratory behaviour and to assess anxiolytic property of hydro-alcohol extract of Lactuca sativa. Diazepam (1 mg/kg body wt.) served as the standard anxiolytic agent for all the tests. The dried extract of the plant leaf in doses of 100, 200 and 400 mg/kg body weight was administered orally to mice for duration of 15 or 30 days and evaluated exploratory behaviour, locomotor and anxiolytic activities. Results: Time spent and number of entries into the open arm was measured in EPM followed by total locomotor activity in OFT and latency to enter the food zone in hyponeophagia. Conclusions: The study suggested that hydro-alcohol extract of Lactuca sativa leaves possess potent anxiolytic property
Emerging 2014 African Ebola: relationship between clinical presentation and mortal outcome
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Academic contends on the paper published in Vol. 4, No. 4, S199-203, 2014
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Repellent activity of the creams formulated from Annona senegalensis and Boswellia dalzielii leaf fractions and essential oils against Anopheles gambiae (Diptera: Culicidae)
Objective: To investigate the repellent efficacy of the creams formulated from methanol extract and n-hexane, chloroform, ethyl acetate and methanol fractions as well as essential oils of Annona senegalensis (A. senegale...
Seasonal prevalence of paramphistomosis in domestic ruminants in different agro-climatic zones of Uttarakhand, India
Objective: To establish the epidemiology of paramphistomosis in Hills and Tarai region of Uttarakhand state, India for the period from 2005 to 2007. Methods: For this purpose, 11 278 faecal samples (4 391 cattle, 2 197 b...
Seroprevalence and epidemiological status of dengue viral infection in remote areas of Pakistan
Objective: To investigate the epidemiological status of dengue viral infection and associated risk factors in Khyber Pakhtunkhwa, Pakistan. Methods: A total of 302 clinically suspected cases of dengue were enrolled in th...