Effects of Melatonin on Primary Oral Wound Healing in Rats
Journal Title: Journal of Applied Veterinary Sciences - Year 2022, Vol 7, Issue 1
Abstract
This study aimed to investigate the effects of melatonin on primary wound healing of the oral mucosa in rats. Thirty healthy male albino rats were used in this study, almost at the same weight, age, and circumstance. All animals were submitted to operation in the buccal mucosal region. Each animal was given a mixture of xylazine and Ketamine hydrochloride Intraperitoneal (I.P.). After about 5 minutes, anesthetic integrity was checked by testing rats' reflexes. After complete anesthesia, each animal was laid down on the dorsal recumbency, via intraoral approach, a full-thickness soft tissue incision 0.5cm length in the right buccal mucosa. The incision was closed by a single simple interrupted stitch using a 5/0 silk suture to heal by primary intention. The animals were randomly divided into two main groups: control group (n=15) and melatonin (n=15)group, which receives melatonin (10 mg/kg/daily) solution orally, then each main group were subdivided into three subgroups (each group 5 rats ) according to the time of sacrifice 3rd,7th and 9th days after surgery respectively. Biopsies were taken from the site of operation and examined by three histopathologists. The statistical analysis showed significant differences in the inflammatory response between the melatonin-treated and control group at all periods of healing. There were significant differences in granulation tissue formation between the melatonin-treated and control groups at the 7th and 9th day healing times. Also, a significant difference existed in reepithelialization between the melatonin-treated and control groups at the 9th day periods of healing. This study concluded that the melatonin appeared good healing accelerator of oral soft tissue healing in rats .
Authors and Affiliations
Saja M. Mohammed, Mohammed S. Sulaiman and Ghada A. Taqa
Keywords
Related Articles
- EP ID EP698582
- DOI https://dx.doi.org/10.21608/javs.2021.98771.1108
- Views 93
- Downloads 0
Enumeration, identification, and antibiogram of some pathogenic bacteria recovered from diseased farmed Clarias gariepinus (Burchell, 1822)
Prevalent etiological agents and treatment options are essential for diagnosing and managing fish diseases. Therefore, in this study, enumeration and identification of the total bacterial count in water, skin, and gastro...
Gangrene of the Tongue Develops 48 Hours Following Ovariohysterectomy as a Treatment of Open-Cervix Pyometra in a Bitch
This case report describes, for the first time, a simultaneous occurrence of open-cervix pyometra and gangrene of the tongue in a ten-year-old intact female Griffon dog. The bitch had a three-week history of grayish blac...
Evaluation and Comparison of Four Screening Tests against Milk Culture for Detection of Subclinical Mastitis in Lactating Cattle and Buffalo in Egypt
Subclinical mastitis (SCM) is an asymptomatic worldwide udder infection that results in substantial losses to the dairy industry. Our main objective was to evaluate and compare the clinical performance of 4 commercially...
Effect Of Garlic As Feed Additive On Performance, Carcass Characteristics, And Meat Quality Of Muscovy Ducks Reared In Different Stocking Densities
This study was carried out to evaluate the effect of supplementing diet with different garlic powder concentrations (300 and 600gm/Ton) on performance, carcass characteristics and meat quality (fat %) of Muscovy ducks ex...
An Overview of Early Development of Mesonephric System in Camels (Camelus dromedarius) with Special Emphasis on Mesonephric Kidney: Structure and Function
This study aimed to examine the features of the mesonephric system in fourteen (14) dromedary camel fetuses. Standard anatomical, histological, histochemical and scanning electron microscopic procedures were applied to i...