EFFECTS OF METHANOIC EXTRACT OF CAPSICUM ANNUUM (CHILLI PEPPER) ON BIOCHEMICAL PARAMETERS AND BLOOD GLUCOSE LEVEL IN WISTAR RATS.
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 5
Abstract
Objective: The current study investigated the effects of methanoic extracts of capsicum annum on biochemical parameters and blood glucose levels in male and female wistar rats. Materials and Methods: A total of 33 wistar rats (12 females and 21 males) weighing between 80g and 120g were used in the study. These animals were divided into ve groups (six rats each, for groups 1 and 2 and seven rats each for groups 3, 4 and 5). Group 1 served as controls and was only allowed access to grower's mash feed and water ad libitum. Groups 2, 3, 4 and 5 served as the test groups and were administered 5mg/kg bw, 10kg/kg bw, 15mg/kg bw and 20mg/kg bw of methanoic extract of Capsicum annum fruit respectively (these groups of rats were equally allowed access to grower's mash feed and tap water ad libitum). The treatment lasted for four (4) weeks after which the animals were anaesthetized and blood samples harvested from them via cardiac puncture. Serum of each sample obtained after proper centrifuging were subjected to biochemical analysis using biochemical analyzer (Reotron Plus). Animals in the respective groups from which blood glucose levels were measured had their tails pricked and about 0.6μl of blood obtained and dropped on the oxidase reagent impregnated spot on the ONE-TOUCH® strip inserted in a glucometer. Result: Values from the various laboratory screenings of the present study, were subjected to statistical analyses (using the statistical package for social sciences-SPSS) and the results showed signicant increases (p<0.05) in the test groups' levels of aspartate aminotransferase (AST), Alanine aminotransferase, (ALT), Alkaline phosphatase (ALP) as well as signicant (P<0.05) decreases in blood glucose levels of all test groups' animals. Conclusion: Considering the outcome of the current study, it implies that that consistent consumption of capsicium annum (chilli peppers) may possibly impair liver functions or damage it. This extrapolation is due to the raised levels of AST, ALT, and ALP, however, mild consumption of the same plant, could be of therapeutic benets, as seen in its blood glucose reduction potentials. The current study therefore, recommends that Capsicum annum (chilli pepper), should be consumed mildly (particularly in hyperglycemic conditions), in order to achieve its benecial properties.
Authors and Affiliations
Odia, K. M, Gwotmut Gwotmut
Keywords
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