THE HEALING EFFECTS OF HYDROALCOHOLIC EXTRACT OF HYPERICUM PERFORATUM ON EXPERIMENTAL CORNEAL INJURY IN RABBIT
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 9
Abstract
Background: corneal alkali injury is one of the most important of eye defects. An epithelial recovery is the most important issue, so drug therapy is essential to facilitate epithelialization again. Methods: The corneal ulcer induced by NaOH on rabbit's eye. Animals were randomly divided into 7 groups of 7 including, sham group, betamethasone, chloramphenicol, negative control group, 1 mL of 1%, 2% and 4% H. perforatum extract respectively. On day-2, the tissue samples of aqueous humor and vitreous humor were obtained from rabbit's eye. Results & Conclusion: The aqueous humor concentration of MDA and NO, corneal inammation and edema in therapeutic groups that receiving the H. perforatum extract at doses of 2 and 4% especially at dose of 4%, were lower than that of negative control group. In conclusion the extract had healing effects in corneal ulcer possibly due to antioxidant and anti-inammatory effects.
Authors and Affiliations
Mehdi Ghahramanifar, Bahman Sharifi, Masoud Haghani, Ali Ghadimi Moghadam, Hossain Sadeghe, Hebatollah Sadeghe, Abdolkarim Ghadimi Moghadam
Keywords
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