EFFECTS OF METHANOLIC EXTRACT OF ALPINIA GALANGA FROM MANIPUR (INDIA) ON UTERUS OF OVARIECTOMISED C3H ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Methanolic extract of shade dried rhizome of Alpinia galanga (MAGE) was prepared using Soxhlet apparatus through a minimal of 18 hrs running. Working doses of the MAGE were determined after LD50 study selecting two doses of 200mg/kg Bwt/day and 500mg/kgBwt/day. The ovariectomised mice were randomly allocated into four groups (n=6) viz. vehicle control (1% tween 80), positive control (E2), low dose MAGE (200mg) and high dose MAGE (500mg). After 7 days of oral treatment, animals were sacrificed by cervical dislocation. Sample tissues were carefully collected and weighted using Sartorius balance. Morphological observations revealed that E2¬ treated group showed positive sign of exogenous estrogenic activity by increasing uterine wet weight and relative increase in uterine/body weight ratio. While low dose MAGE treated group shows weak estrogenic activity by increasing uterine wet weight and uterine/body weight, but less pronounced than E2 treated group. The high dose MAGE treated group showed no estrogenic activity rather showed decrease uterine wet weight as well as morphologically constricted uterine horns which clearly suggests anti-estrogenic activity. The present study provides initial evidence towards establishing either estrogen agonistic or antagonistic hormonal property of MAGE in in vivo animal model.
Authors and Affiliations
Rajeevkumar Yungkham , Chandra Jogen
Keywords
Related Articles
- EP ID EP140459
- DOI -
- Views 69
- Downloads 0
RIVAROXABAN: AN ORAL DIRECT INHIBITOR OF FACTOR X-A
Venous thrombo embolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality in patients undergoing major orthopaedic surgery, and routine thrombo prophylaxis has...
TRACHYSPERMUM AMMI (AJWAIN): A COMPREHENSIVE REVIEW
The use of plants as medicine is as old as human civilization. People of all ages in both developing and developed countries use plants in an attempt to cure various diseases and to get relief from physical sufferings. N...
FORMULATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS
The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration superdisintigrents.Fast dissolving tablets of Aceclofenac were prepared by wet granulation technique using s...
BREAST CANCER RISK FACTORS: PREVENTABLE AND NON-PREVENTABLE
Worldwide, breast cancer comprises 22.9% of all cancers (excluding non-melanoma skin cancers) in women. The incidence of breast cancer is rising in every country of the world especially in developing countries such as In...
ASSESSMENT OF THE ROLE OF PSEUDOMONAS FLUORESCENS AS BIOCONTROL AGENT AGAINST FUNGAL PLANT PATHOGENS
Isolates of Pseudomonas were purified from the natural environment and characterized morphologically and biochemically. Evaluation of antifungal activity against five fungal plant pathogens (Fusarium oxysporum, Aspergill...