STUDY ON INVITRO PERMEATION ENHANCEMENT OF KETOPROFEN BY FORMATION OF SOLID DISPERSION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
Solid dispersions of ketoprofen were prepared by using different water soluble carriers like β-cyclodextrin, PEG 6000, polyvinyl pyrolidone and urea in appropriate concentration to enhance the transdermal flux. The prepared solid dispersions were characterized by IR spectroscopy & DSC suggested no interaction of drug with carriers. The solid dispersions were evaluated for solubility, Invitro dissolution and Invitro permeation through rat skin. The solubility of ketoprofen was enhanced 3-7 times in order of solid dispersion, urea<PV<PEG 6000<β-cyclodextrin and also was increased with increase in the concentration of carriers. The dissolution of all ketoprofen solid dispersions was 67.45% to 95.41% more as compare to the pure drug (24.46%) after 120 min. The percentage drug dissolution was increased for the different carrier as urea<PVP<PEG 6000<β-cyclodextrin and also as the concentration of carriers increase the dissolution was also increased. The in vitro dissolution was correlated with the solubility study. The flux obtained for all solid dispersion was 3-8 times more as compare to pure drug due to enhanced solubility and dissolution of ketoprofen in donor compartment. The highest flux was obtained with β-cyclodextrin (446.31mcg/cm2/h) and PEG 6000 (432.22mcg/cm2/h). Hence the permeation flux of ketoprofen could be enhanced by formation of solid dispersion for effective topical preparations.
Authors and Affiliations
Saleem M. A , Vishal Singh , Khalid S , Sudhir Pange , Omair Ahnaf
Keywords
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