EFFECTS OF RICE BRAN OIL AND GAMMA - ORYZANOL ON ANTIOXIDANT DEFENSE IN STREPTOZOTOCIN NICOTINAMIDE INDUCED DIABETIC RATS
Journal Title: International Journal of Engineering Sciences & Research Technology - Year 30, Vol 4, Issue 6
Abstract
Rice bran oil (RBO), a unique cooking oil is produced from the pericarp and germ of Oryza sativa seeds. Oryzanol is a mixture of sterol esters of ferulic acid and is known to have several health benefits. Male albino wistar rats were rendered hyperlipidemic by feeding high fat high cholesterol diet and diabetic by single intraperitoneal injection of freshly prepared streptozotocin [60 mg /kg b.w.] along with nicotinamide (NA) (120 mg/kg, i.p). Animals were suppl emented for a period of 42 days with Rice Bran Oil (RBO) [15%] singly; blends of rice bran oil and oryzanol ( RBO - OZ - 100) with RBO (15%)and OZ at 100mg/Kg body weight and Oryzanol ( OZ - 100) singly at 100mg/Kg body weight. Glibenclamide (5mg/kg body weight) was used as a standard reference drug. Serum and tissues (liver kidneys and pancreas) were investigated for its antidiabetic, antihyperlipidemic and antioxidative efficacy in rats. High fat - high cholesterol feeding (HFHC) and STZ - NA induced diabetes resul ted in significant increase in blood glucose, lipid – lipoprotein fractions and oxidative stress biomarkers in serum and tissues of rats. Treatment with RBO and oryzanol significantly (p≤0.05) restored the biochemical indices near to normal. The effect of RBO - OZ - 100 and OZ - 100 was better than glibenclamide. Results suggest that RBO and OZ efficiently regulated blood glucose; ameliorated lipid abnormalities associated with diabetes and improved the antioxidant enzymatic status in STZ - NA diabetic rats by virt ue of bioactive compounds. The therapeutic potential of RBO and OZ can be used as preventive and protective therapy against the detrimental effects of diabetes and associated hyperlipidemia.
Authors and Affiliations
C. Komal* , C. Bhushan , B. Gauri
Keywords
Related Articles
- EP ID EP163623
- DOI -
- Views 122
- Downloads 0
A New Approach of Multicasting in Cloud Computing
Cloud Computing is the emerging and prominent technology in IT world. Rather than setting up, the infrastructure, platform and services separately for each and every IT industry, are kept collaboratively, which can be...
UP GRADATION OF LIGNITE COAL BY WET SIEVE TECHNIQUE FROM MATASUKH MINES OF NAGAUR, RAJASTHAN, INDIA
Energy consumption per capita in modern society, The drastic development in industrial sector, commercial sector due to tomization the energy supply was started by lignite coal along with other energy source in w...
Reduction of Multipliers in FIR Filter Using Various Algorithms-Review
Due to the explosive growth of digital signal processing applications, the demand for high performance and low power is getting higher and higher.Finite-impulse response digital filters(FIR) are one of the most wi...
Formulate a Hit Item Replacement and Propose Cluster Ensembling (CE) Algorithm for Data Compression
In this paper, we first propose an efficient distributed mining algorithm to jointly identify a group of moving objects and discover their movement patterns in wireless sensor networks. Afterward, we propose a co...
An Innovative Cryptographical Scheme for Mobile Ad-Hoc Network Security using Certificate less Public key Cryptography
A Mobile ad hoc Network (MANET) is a self-governing network comprised of free roaming nodes which communicate wireless by radio transmission. As MANET edge closer toward wide-spread deployment, security issues ha...