EFFECTS OF STRONTIUM CHLORIDE HEXAHYDRATE IN CAENORHABDITIS ELEGANS INDIVIDUALS AS A MODEL FOR SKIN AGING
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 12
Abstract
Backround: Collagen destruction is related to the presence of matrix metalloproteinase (MMP) that are released by epidermal keratinocytes and dermal fibroblasts and the MMP-1 expression stimulated by ultraviolet radiation is provided by the protein kinase C-dependent (PKC)-dependent activation of transient receptor potential vanilloid 1 (TRPV-1) in human keratinocytes and subsequent calcium (Ca2+) transition. Strontium is a an alkaline-earth metal with chemical and biological behaviors similar to calcium. Objective: To investigate whether strontium chloride hexahydrate has anti-aging effects on Caenorhabditis elegans. Materials and Methods: After treatment with strontium solutions, the lifespan, physical development and pharynx pumping numbers of C.elegans were determined and compared with the control group. Results: An increase in strontium-exposed C.elegans depending on the dosage increase in their lifespans was specified. İt was determined that physical development in strontium-exposed C. elegans decreased depending on the dosage. It was specified that pharynx pumping count per minute decreased depending on the strontium dosage. Conclusion: Strontium chloride hexahydrate slowed down the developmental process of C.elegans and extended their lifespans. Strontium chloride hexahydrate may have a positive effect on skin aging in humans with similar mechanisms.
Authors and Affiliations
Dr. Rukiye Güner
Keywords
Related Articles
- EP ID EP646160
- DOI -
- Views 137
- Downloads 0
ANTIBACTERIAL ACTIVITY OF DAUCUS CAROTA (CARROT) PEEL EXTRACT ON SOME SELECTED CLINICAL ISOLATES FROM MARYAM ABACHA WOMEN AND CHILDREN HOSPITAL, SOKOTO
The antibacterial activity of Daucus carota (Carrot) peel extract was evaluated using clinical bacterial isolates obtained from Maryam Abacha Women and Children Hospital, Sokoto. Active constituents of Daucus carota peel...
BANGUN-BANGUN TABLET FORMULATION WITH PVP K-30 AS TABLET BINDER
Bangun-bangun leaves is one of Indonesia heritage plants used for medicine and days consumption. There are some research with bangun-bangun leaves have already conduct to get the best formulation and effectivity. The obj...
EFFECT OF SHRIMP SHELL EXTRACT NANOPARTICLES ON ORAL SQUAMOUS CELL CARCINOMA CELL LINE: IN VITRO STUDY
To develop a shrimp shell extract based nanoparticles formulation and assess its effect on the viability and carcinogenic potential of human oral squamous cell carcinoma cell line Hep-2 in vitro. Nanoparticles of chitosa...
INTRANASAL DEXMEDITOMIDINE AND INTRANASAL MIDAZOLAM AS PREMEDICATION IN PEDIATRIC SURGICAL PATIENTS
Background: Many routes and drugs have been studied for premedication in pediatric surgical patients. Intranasal being one of them. Ease of administration makes it one of the preffered routes. Objectives: To evaluate the...
PRELIMINARY PHYTOCHEMICAL SCREENING, IN VITRO THROMBOLYTIC AND MEMBRANE STABILIZING ACTIVITIES OF GYNURA NEPALENSIS LEAVES OF BANGLADESHI ORIGIN
Gynura nepalensis (Family: Asteraceae), is one of the commonly used medicinal plants that was investigated for in vitro thrombolytic and membrane stabilizing activity. People of Bangladesh have been using this herbaceous...