Effects of thalidomide on the development of bone damage caused by prednisolone in rats.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 2
Abstract
Background: The methods used in treatment of osteoporosis induced by glucocorticosteroids are not effective enough. There is a need for new drugs which could be useful in counteracting the influence of glucocorticosteroids on osseous tissue. The aim of the present study was to investigate the effects of thalidomide on the development of osteoporosis induced by glucocorticoid (prednisolone) in rats. Methods: The experiments were carried out on 3-month-old male Wistar rats. The animals were divided into 4 groups: I - control rats; II - prednisolone (10 mg/kg po); III - prednisolone (10 mg/kg po) + thalidomide (15 mg/kg po); IV - prednisolone (10 mg/kg po) + thalidomide (60 mg/kg po). The drugs were administered for 3 weeks. The body mass gain, bone mass in the tibia, femur and L-4 vertebra, histomorphometric parameters of the tibia (width of osteoid, diaphysis transverse growth, area of the transverse cross-sectional of the bone marrow cavity and the cortical bone) and the femur (width of trabeculae, width of epiphyseal cartilage, diaphysis transverse growth, area of the transverse cross-sectional of the bone marrow cavity and the cortical bone) were studied. Results: Prednisolone induced osteoporotic skeletal changes in mature male rats (decreases in the bone mass, the width of the periosteal and endosteal osteoid, the transverse cross-sectional area of the cortical bone, the width of trabeculae, and the diaphysis transverse growth were observed). Thalidomide administered at a dose of 15 mg/kg po inhibited the development of changes in macrometric and histomorphometric parameters induced by prednisolone in the skeletal system of rats. Conclusion: The results may constitute indirect evidence for possible clinical trials conducted in order to define the possibility to apply thalidomide in treatment of bone diseases in humans.
Authors and Affiliations
Ilona Kaczmarczyk-Sedlak, Maria Zych, Katarzyna Rotko, Lech Sedlak
Keywords
Related Articles
- EP ID EP92689
- DOI -
- Views 89
- Downloads 0
Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats.
The present study was designed to find out whether pharmacological activation of GABA(B) receptors played a role in cocaine sensitization. To this end, male Wistar rats were injected with baclofen or 3-aminopropyl(methyl...
Hemostatic effects of simvastatin in subjects with impaired fasting glucose.
The aim of our study was to compare the effect of simvastatin on a range of hemostatic variables in subjects with impaired fasting glucose (IFG) and isolated hypercholesterolemia. We enrolled 28 subjects with IFG, 25 pri...
Effect of fluoxetine on tolerance to the analgesic effect of morphine in mice with skin cancer.
Adjuvant drugs that attenuate or inhibit the development of tolerance to morphine may lead to improved management of pain in chronic diseases such as cancer. The aim of this study was to investigate effect of fluoxetine,...
Antidepressant-like effect of chromium chloride in the mouse forced swim test: involvement of glutamatergic and serotonergic receptors.
Chromium (Cr) (III), an essential microelement of living organisms, was reported to exhibit potential antidepressant properties in preclinical and clinical studies. The aim of the present study was to examine the effect...
Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia.
Background: Accumulating evidence indicates that mangiferin (MGF), a natural xanthone, by virtue of its antioxidant and antiinflammatory properties is neuroprotective. Here we sought to verify the cytoprotective role of...