Effects OfMetformin On Thyroid Profile In Patients Of Subclinical Hypothyroidism Attending OPD Of A Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background: Subclinical hypothyroidism (SCH) defined as an elevated serum Thyroid Stimulating Hormone (TSH) level with a normal serum free thyroxine (fT4) concentration 1 . SCH can progress to overt hypothyroidism. In this study we can see effect of metformin among SCH patients. Methodology: The study was conducted at Midnapore Medical College. This unicentric, hospital based single arm prospective interventional study included 96 new cases of SCH patients age 18-60 years with TSH level 5- 10 mIU/L and normal fT3 & fT4. Metformin prescribed 2,000 mg daily into two divided doses for 12 weeks 2 . Serum fT3, fT4 and TSH level were measured by ELISA. Statistical comparisons performed by “Paired t test”. Results: 96 patients (15 male, 81 female) mean age was 36.18±11.57 years. Comparison of TSH levels of study subjects before starting metformin therapy and 8 weeks after therapy and also before starting metformin and 12 weeks after therapy, by “Paired t test”. Significant reduction in TSH level was seen at the end of 12 weeks (P < 0.001). Conclusion: Metformin can decrease TSH level in SCH patients without significant alteration of fT3 & fT4 levels. Further studies required to establish effects of metformin in long term use in SCH.
Authors and Affiliations
Dr. Mallika Biswas, Dr. Tarun Biswas
Keywords
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- EP ID EP373983
- DOI 10.9790/0853-1705025357.
- Views 86
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