EFFECTS ON HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL CHANGES AFTER PRETREATMENT WITH THE KCNQ OPENER RETIGABINE AND DIACYGLYCEROL LIPASE INHIBITOR ON PROPOFOL IN THE MICE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
The mechanisms of action of general anesthetics are still being unraveled. Retigabine is a KCNQ/Kv7 channel opener and has potential therapeutic importance for epilepsy. On the other hand, Propofol an inducing general anesthetic drug may modulate the ATP sensitive channels according to recent reports. This study was conducted to evaluate the effects of the KCNQ potassium channel opener drug retigabine and DAG lipase inhibitor, RHC 80267 on propofol mediated effects on blood pressure, heart rate and hematological parameters like the RBC, WBC, hemoglobin and serum alanine and aspartate amino-transferase enzymes in the mice.
Authors and Affiliations
Subramaniam Kannan| Department of Pharmacy Practice and Pharmacology1, JKKMMRFS College of Pharmacy, Komarapalayam, 638183, TN, India., V Suresh| Department of Pharmacy Practice and Pharmacology1, JKKMMRFS College of Pharmacy, Komarapalayam, 638183, TN, India., Aniket Kumar| Department of Pharmacology, Christian Medical College, Vellore 632002,, K Arumugasamy| Department of Pharmacology, Christian Medical College, Vellore 632002,, Manoj G Tyagi| Department of Pharmacology, Christian Medical College, Vellore 632002,
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