Efficacy and safety of fixed dose combination of drotaverine hydrochloride (80 mg) and mefenamic acid (250 mg) versus mefenamic acid (250mg) alone in treatment of primary dysmenorrhea : double-blind, randomised comparative study.
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 7
Abstract
To compare the effect of combination of Mefenamic acid and Drotaverine hydrochloride with Mefenamic acid alone in primary dysmenorrhea. Out of 180 women with diagnosis of primary dysmenorrhea 87 women (Group A) were given combination of mefenamic acid 500mg with drotaverine 80 mg, while 93 women (Group B) were given Mefenamic acid 250 mg thrice a day during menstruation. Various pain intensity and relief scores were observed before and after treatment. The baseline characteristics and average pain score were similar. Post treatment pain intensity scores were significantly less in group A as compared to group B (p=0.001). The pain relief scores, patients satisfaction score and clinicians score were significantly higher in group A as compared to group B (p=0.001). Combination of mefenamic acid with drotaverine achieves significantly higher success in pain relief in primary dysmenorrhea as compared to mefenamic acid alone.
Authors and Affiliations
JB Sharma, Alka Kriplani, Sunesh Kumar, KK Roy, Sona Dharmendra, Eshani Sharma, P Vanamail
Keywords
Related Articles
- EP ID EP614247
- DOI -
- Views 151
- Downloads 0
Indications and operative outcomes of acromioclavicular joint injuries fixed with bosworth screw
Acromioclavicular joint is a biomechanically complex joint, isolated injuries of which are rare. Complex classification system (Rockwood) and no universally approved guidelines for the treatment with the ever evolving su...
Insulin use in transplant patients
India is the preferred destination for organ transplant in South-East Asia. Tacrolimus and Prednisolone are commonly used in the immunosuppressive regimens after transplant to prevent allograft rejection. Both of these a...
Suzuki classification : a useful adjunct to michel and hiatt hepatic arterial classification systems
Multidetector Computed Tomography (MDCT) allows non-invasive and accurate preoperative evaluation of hepatobiliary anatomy. Clinician is well versed with relevant hepatobiliary anatomy and can meticulously plan treatment...
Paraneoplastic cerebellar ataxia as the initial manifestation of occult fallopian tube carcinoma : a case report
A 54-year-old post-menopausal lady, from rural Bengal, presented in our neuromedicine outdoor with a history of subacute onset, progressive unsteadiness of gait, incoordination of limbs, slurring of speech and significan...
Oral Betamethasone-azathioprine pulse : a patient compliant modification of Dexamethasone cyclophosphamide pulse therapy for pemphigus
Pemphigus vulgaris (PV) is an autoimmune vesicobullous disorder in India with a very high mortality rate (>90%) if untreated. Immunosuprresives are the mainstay of treatment. Dexamethasonecyclophosphamide pulse (DCP) the...