Efficacy and Safety of Herbal Formulations Used For Management of Hiv/Aids In Mombasa County
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 1
Abstract
Background: Traditional medicines are not understood globally and hence are not fully exploited. Pwani herbs clinic in Mombasa dispenses herbal medicines to manage HIV and AIDS. There was need to subject these herbs to formal clinical research to ascertain their efficacy and safety. Objectives: To isolate the components of the herbal formulations Antiretroviral herbal formulation (VIRAD) and immune boosting herbal formulation (IMB) and determine their efficacy and safety. Design: A longitudinal study for People Living with HIV/AIDS (PLWHA) attending Pwani herbsclinic and measure physiological, immunological and Viral Load parameters. Period of study was one year; patients were screened at every two months. Every sample was its own control from baseline. Settings: Pwani herbs Clinic Mombasa and Laboratory analysis done at Bomu Medical clinic in Mombasa. Study participants: Adult male and female patients confirmed HIV positivethat use herbal treatments for management of HIV/AIDS disease/status. Results: Phytochemical components (mg/100g); Virad; Phenols 84.4mg, Saponins 531mg, Tannins 324mg, Alkaloids 2304mg, Flavonoids 2173mg, Protein 442mg and Lipids 2444.2mg. Trace elements µg/g) K 12922±103Na 475±4 Ca8861±71 Mg547±1 Fe361±4 Cu 98.6±1.5 Zn43.7±0.9.IMB; Phenols 75.1mg, Saponins564mg, Tannins 51mg, Alkaloids 1531mg, Flavonoids 2533mg, Proteins 544mg, Lipids 2553.8mg.Trace elements (µg/g) K 12085±87 Na 598±11 Ca 6047±46 Mg 545±1 Fe348±4 Cu 5.9±0.4 Zn25.3±0.6.At months 2, 4, 6, 8 and month 10, 23/188 discontinued. Out of these 3 died while 20 developed other complications such as tuberculosis and cancers were discontinued from study.At completion of study weight gained by average 17kg, BMI increase 4.85, CD4 raise 126, CD8 declined 15, CD4/CD8 raise 0.19, Viral load drop 864, Hemoglobin Hb raise 3g/dl, RBC raise 1.3, WBC raise 1.6, ESR drop 21. Toxicity on kidney Urea drop 0.1g/dl, Liver GGT, AST, ALT drop0.3g/dl. Virad and IMB; Flavonoids, Alkaloids and lipids were of highest concentrations in these formulations have antioxidant molecules that positively affect physiological and immunological factors, boost immunity, raise CD4 count and raise CD4/CD8 ration and decrease viral load. Not harmful on Endocrine organs Liver & kidney. Virad and IMB have virastatic effects and could be considered for development and subsequent inclusion in management of HIV/AIDS. Conclusions: Virad and IMB were effective and safe with virastatic potentials to use on people living with HIV/AIDS. More study is needed for long term treatments
Authors and Affiliations
Mwavita A. L, Muturi M, Njagi E, 3mbugua G. G
Keywords
Related Articles
- EP ID EP394228
- DOI 10.9790/3008-1301062735
- Views 64
- Downloads 0
Retrograde Cystourethrogram Findings in Patients with Suspected Uretharal Strictures In Yenagoa, Nigeria
A retrograde cystourethrogram (RCUG) in conjunction with a voiding cystourethrogram (VCUG) or intravenous urethrogram (IVU) serve as the gold standard for the diagnosis of a urethral stricture. In this study, we reviewed...
Phytochemical Screening and in-vitro Anti-Inflammatory Activity of Methanolic Extract of Sterculia foetida L.
Sterculia foetida (S. foetida) is a tall tree located in India, Malaysia and North East Australia. Decoction of bark in folklore medicine was used for the treatment of dropsy and rheumatism. The main focus of this work w...
Pattern, Knowledge And Other Contextual Correlates Of Use Of Pain-Killers Among Students Of Niger Delta University
Pain, a ubiquitous symptom in the clinics, requires the use of analgesics to manage. Analgesics have been reported to be very widely used and abused set of drugs globally. This study was aimed at evaluating the patterns...
Effect of Aqueous Leaf Extract of Vernonia Amygdalina on Blood Glucose and Lipid Profile of Alloxan-Induced Diabetic Rats.
The effects of orally administered aqueous leaf extract of Vernonia amygdalina on serum glucose and lipid profile of albino rats were determined. Adult healthy rats of both sexes of about eleven weeks old were randomly a...
Role of Presenilin-1 in Modulating Glycogen Synthase Kinase 3 β Expression in the Pathogenesis of Alzheimer’s Disease
Context: Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by the presence of neurofibrillary tangles (NFT) and senile plaques caused due to amyloid beta (Aβ) peptide localization in the brai...