Hepatoprotective Activity of Methanolic Extract of Whole Plant of Pulicaria Wightiana L. against Carbon Tetrachloride and Paracetamol -Induced Hepatotoxicity in Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of Pulicaria wightiana in wistar rats. The studies were conducted using the two popular inducing agents Paracetamol (2 g/kg, p.o.) in 1% NaCMC and Carbon tetrachloride (1 ml/kg). Silymarin (100 mg/kg, p.o.) was used as reference drug in the respective models. The effect was estimated by measuring the enzymatic levels and histo- pathological studies. The methanolic extract of whole plant of Pulicaria wightiana has shown very significant hepatoprotection against both Paracetamol and CCl4 - induced hepatotoxicity study models in wistar rats. This was evidenced by marked reduction in marker enzymes in serum. Histopathological studies also confirmed the hepatoprotective nature of the extract.
Authors and Affiliations
S. Nelson Kumar, K. Ravindra Reddy, K. B. Chandra Sekhar2, J. P. Yanadaiah1, Rakhal Chandra Das3
Keywords
Related Articles
- EP ID EP387291
- DOI 10.9790/3008-1201010107 .
- Views 100
- Downloads 0
Effect of Dietary Restriction on Survival, Longevity and Fecundity of Blowfly Chrysomya Chloropyga (Wied.) (Diptera: Calliphoridae)
Dietary Restriction (DR) was used to determined the survival, longevity, adult weights and fecundity of adult reared blowfly Chrysomya chloropyga.Twenty males and 20 females each were put in cages and exposed to continuo...
Hepatoprotective and Antioxidant Effects of the Flavonoid-rich Fraction of the Methanol Extract of Jatropha tanjorensis Leaves in CCl4-induced Liver Injury in Rats.
The leaves of Jatropha tanjorensis are edible and used in herbal medicine in the treatment of diseases associated with oxidative stress. The present study demonstrates the antioxidative effect of the flavonoid-rich fract...
Evaluation of Immune Response to Measles Virus Antigen
Increasing of measles infection cases in last few years is an important issue, which must be dealing with to assess the reasons. Immunizing lab animals with measles vaccine to is a better way understanding of vaccine-ind...
Evaluation of serum iron and ferritin in different treatment regimens for chronic hepatitis C virus
This work aims to develop a biochemical study on the effect of both interferon containing treatment regimens and interferon free regimens on serum iron and serum ferritin in patients with chronic hepatitis C and to evalu...
Sex hormones profiles in Iraqi males patients with symptomatic cholelithiasisbefore cholecystectomy
Gallstone disease (GD) is a worldwide disease and it remains to be one of the most common health problems leading to surgical intervention. GB stone formation is multifactorial &many theories have been put forwardto expl...