Efficacy and safety of oral fluconazole vs topical antifungal imidazoles in tinea corporis: A comparative therapeutic trial
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 6, Issue 1
Abstract
Background:Dermatophytes are the most common causes of superficial fungal infections worldwide. All dermatophytosis of glabrous skin except the palms, soles and groin are categorized under tinea corporis. Dermatophytic infections may be treated with both topical and systemic therapies. The present study aims to assess the efficacy and safety of oral fluconazole in comparison to topical antifungal miconazole nitrate and ketoconazole against tinea corporis.Methodology:This study is an open labelled comparative trial. About 60 patients (n =60) with dermatophytosis attending outpatient clinic of dermatology department of Government Medical College, Kozhikode, Kerala, India, were selected randomly. The diagnosis and prognosis was done by clinical and microscopic examination by mounting skin scrapings in 10% KOH solution. The comparison of efficacy was done by chi-square test. The cure rate in each group was expressed as percentage.P value of <0.05 was considered significant and <0.01 as highly significant.Results: The cure rate in tinea corporis with oral fluconazole therapy at the dose of 150 mg weekly for 3 weeks was 100 %. The cure rate observed with miconazole and ketoconazole were 60% and 53% respectively.Fluconazole treatment does not resulted in serious adverse effects and safer for short term therapy of tinea corporis.Conclusion: Oral fluconazole is more effective than topical antifungal agents like miconazole nitrate and ketoconazole for the treatment of tinea corporis.
Authors and Affiliations
Mohamed Salim Valiyakathoy, Soopy Kayanaduth, Roopashree Gopinath
Keywords
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