Efficacy and Safety of Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Journal Title: Journal of Cancer and Tumor International - Year 2016, Vol 3, Issue 1
Abstract
Aims: Advanced Hepatocellular carcinoma (HCC) is a major health problem with limited treatment options. The Sorafenib monothearpy is the only efficacious systemic treatment agent showing a survival benefit in these patients. In our study, we evaluated the efficacy and tolerability of Sorafenib in advanced and metastatic HCC patients. Methodology: Twenty patients with advanced HCC (between Jan. 2011 and Dec. 2013), and not eligible for loco regional therapy were treated prospectively with Sorafenib monotherapy with assessment of survival and toxicity. Follow up was until Oct. 2014. Results: According to Eastern Cooperative On¬cology Group (ECOG) performance status (PS) of 2 was found in the most of patients 13/20 while Ps 3 in 7/20 and Child-Pugh class A in (40.0%) of cases and B (60.0%) of patients. Six patients had stage IV-A tumors, whereas 14 had stage IV-B tumors. Four patients had portal vein tumor thrombosis (PVTT). Following Sorafenib monotherapy, the disease control rate was( 65.0)% with 5 patients (25.0%) had a parial response while stable disease in 8 patients (40.0%) with a median overall survival of 12 months and the median progression-free survival was 0 months. Diarrhea and hand-foot skin reactions were the major side effects. Conclusions: In our study, the use of Sorafenib monotherapy in the patients with advanced HCC showed a reasonable outcome and was well tolerated. Further study with a larger number of patients and treated with a long duration is warranted.
Authors and Affiliations
Yasser M. Saleh, Waleed Hammam
Keywords
Related Articles
- EP ID EP242952
- DOI 10.9734/JCTI/2016/22142
- Views 92
- Downloads 0
Antineoplastic Activity of the Ethyl Acetate Extracts from Co-cultured Marine and Terrestrial Actinomycetes
Treatment of cancer is mainly depending on chemotherapy. A considerable number of antitumor compounds are obtained from microorganisms. Particularly, actinomycetes are the sources of a number of compounds with different...
EMPACT Syndrome - Erythema Multiform Due to Phenytoin Associated to Cranial Radio Therapy: Case Report and Review of the Literature
Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis are rare and severe cutaneous syndrome that are usually drug related. Aromatic oral anticonvulsants (e.g.: phenobarbital, phenytoin, carbamazep...
Technetium-MDP Bone Scan/SPECT CT Findings in Erdheim-Chester Disease: A Case Report of Skull and Ribs Involvement
Erdheim-Chester disease (ECD) is a rare disorder of the non-Langerhans cell histiocytes with associated infiltration of multiple organ systems. Skeletal involvement is characteristically bilateral and symmetric, exhibiti...
Outcome and Predictive Factors of Radiation Therapy for Medulloblastoma: Mansoura Experience
Background: Medulloblastomas are the most common infratentorial malignant brain tumors with an incidence rate of 0.5 in 100.000 typically arising in childhood at age 5-9 years. Aim of Work: Exploring the epidemiological...
Detection of EBV and HPV in Oral Squamous Cell Carcinoma and Ameloblastoma: Real Time Polymerase Chain Reaction Study
Background: Head and neck cancer includes several malignancies that originate in the paranasal sinuses, nasal cavity, salivary glands, oral cavity, pharynx, and larynx. The burden of viral infections in cancer is high bu...