Efficacy and tolerability of methyl phenidate and atomoxetine in children with attention deficit hyperactivity disorder –An open label randomized control trial from a tertiary care centre
Journal Title: Indian Journal of Neurosciences - Year 2017, Vol 3, Issue 2
Abstract
Attention Deficit Hyperactivity Disorder is a commonly encountered problem in School aged Children. Recent studies have shown a significant improvement of symptoms with pharmacotherapy. We analyzed the effectiveness of Methyl phenidate and Atomoxetine in ADHD patients. Objective: To compare the efficacy, tolerability and medication adherence of Methyl phenidate and Atomoxetine in Children with ADHD. Study Design: Randomized controlled open label study in children aged 6-12 years with a diagnosis of ADHD as per DSM IV attending the Paediatric Neurology OPD of a Tertiary Care centre. Children were randomized to receive either Methyl phenidate or Atomoxetine for eight weeks. Baseline and post treatment (eight weeks) Attention Deficit/ Hyper Activity Disorder Rating Scale and the Clinical Global Impression Severity of Illness scales were compared between the two groups. Results: There was significant improvement in ADHD symptoms with therapy. The mean reduction in the total Pre and post treatment ADHD RS score from baseline following drug therapy was 17.9 and 15.1 respectively in Methyl phenidate and Atomoxetine groups which was not statistically significant. 67.5% of children on Methyl phenidate showed significant improvement CGI scale compared to 60% on Atomoxetine. There was no significant difference between the groups. Both the drugs were well tolerated.
Authors and Affiliations
Mini Sreedharan, PA Mohammed Kunju, Kalpana Devadathan, Anagha Bhagwat, Kavasseri Neelakantan Janaki
Keywords
Related Articles
- EP ID EP310552
- DOI 10.18231/2455-8451.2017.0010
- Views 83
- Downloads 0
Tibial and peroneal nerve conduction study (NCS): normative data for healthy individual
Context: NCS assess peripheral nerve functions & their parameters. It used to diagnosis of peripheral nerve disorders. So propose of study to establish normative values of Tibial & Peroneal NCV in healthy individuals. Ai...
Alcohol Related Brain Damage in Young Alcoholic
Alcohol is the most commonly abused legal substance in the world. Long term implication of alcohol addiction and its withdrawal have been evident in the past century, since medical science evolved from medieval era to mo...
Hypothyroidism masquerading as cerebellar ataxia
Cerebellar ataxia can be a rare possible presentation of autoimmune hypothyroidism We report a case of a young 20 years old female who presented with bilateral cerebellar ataxia without any other significant neurological...
Idiopathic Intracranial Hypertension (IIH) in a tertiary referral teaching centre in Central India
Idiopathic Intracranial Hypertension (IIH) is mainly a disease affecting women of child bearing age. It is characterized by increased intracranial pressure in the absence of any tumor or other structural brain abnormalit...
Minimally invasive spine surgery: An alternate corridor for various spinal procedures – Our institute experience
Introduction Minimally invasive spine procedures are minimally destructive procedures which minimizes surgery related morbidity by avoiding excessive muscle dissection and reduce tissue trauma during surgery The indicati...