Efficacy of 0.1% adapalene gel in reducing sebum secretion in patients with mild to moderate acne vulgaris
Journal Title: Medpulse International Journal of Medicine - Year 2018, Vol 7, Issue 3
Abstract
Background: Acne vulgaris is a chronic skin disease characterized by comedones, papules, and pustules. Adapalene treatment is found to beto be safe and effective in treating acne vulgaris, reducing inflammatory and noninflammatory lesions. Aim: To evaluate the efficacy of 0.1% Adapalene gel in reducing sebum secretion in patients with mild to moderate acne vulgaris. Material and Methods: A total of 50 patients were given topical 0.1% Adapalene gel on an intent-to-elicit its effect on SER in relation to reduction in lesions in mild to moderate acne. Forty of these completed treatment as per protocol (6-weeks period). Facial sebum secretions were measured using a Sebumeter.® Five different facial sites were selected-forehead (mid glabella), nose (the tip), right and left cheek (the most prominent area of both zygomata and chin (the mental prominence). Results: Mild acne (Grade I) was seen in 22.5%, moderate acne (Grade II) in 42.5% and moderately severe acne (Grade III) in 27.5%.Of the 40 patients who completed 6 weeks of therapy, 90% showed a global improvement in their acne from baseline. About 19 patients (47.5%) showed excellent and another 15 (37.5%) showed a good improvement. Lesions showed poor response in only 4 patients (3%). Average sebum excretion rate of T- Zone at baseline was 91.34±43.26, whereas after 6-weeks treatment it was 82.68±40.50. Conclusion: Treatment with 0.1% Adapalenegel did not show significant decrease in MFSE, even though it significantly reduced acne lesions. This suggestive of other important factors playing vital role in comedogenesis.
Authors and Affiliations
Ajay Govindrao Ovhal, Jerajani H R, Dhurat R S
Keywords
Related Articles
- EP ID EP412622
- DOI -
- Views 93
- Downloads 0
Zink phosphide/Rattol poisoning at rural Konkan region
Background: Zinc phosphide is used as a rodenticide and is available as paste, bait pellets, granules, dust, and tracking powder formulations. In Kerala state zinc phosphide has second highest incidence for intoxicant po...
Metabolic syndrome’s risk factor and relation with coronary artery disease
Background: Metabolic Syndrome (MS) represents a constellation of risk factors. Modified IDF definition for Asian Indian MS is any 3 out of five – abd obesity male 90 cm, female 80cm, fasting blood glucose100 mg, Hy...
Gender impact in diabetic patients with acute myocardial infarction: A hospital-based study
Objective: There are previous studies stating gender differences in clinical profile in diabetics who sustain acute myocardial infarction. This study was undertaken to observe such differences in a small cohort of popula...
A study of prevalence of bronchial asthma and associated precipitating factors in children at tertiary health care center
Background: Asthma is a common chronic respiratory disease affecting children; it is a major health problem in both developed and developing countries Aims and Objectives: To Study of Prevalence of Bronchial Asthma and s...
Clinical profile and risk factors of CT pulmonary angiographically confirmed cases of pulmonary embolism
Background: Pulmonary thromboembolism (PTE) is a major health problem with significant mortality and morbidity. PTE implies occlusion of pulmonary arterial circulation by the clot formed elsewhere usually in deep veins i...