Efficacy of 0.1% adapalene gel in reducing sebum secretion in patients with mild to moderate acne vulgaris
Journal Title: Medpulse International Journal of Medicine - Year 2018, Vol 7, Issue 3
Abstract
Background: Acne vulgaris is a chronic skin disease characterized by comedones, papules, and pustules. Adapalene treatment is found to beto be safe and effective in treating acne vulgaris, reducing inflammatory and noninflammatory lesions. Aim: To evaluate the efficacy of 0.1% Adapalene gel in reducing sebum secretion in patients with mild to moderate acne vulgaris. Material and Methods: A total of 50 patients were given topical 0.1% Adapalene gel on an intent-to-elicit its effect on SER in relation to reduction in lesions in mild to moderate acne. Forty of these completed treatment as per protocol (6-weeks period). Facial sebum secretions were measured using a Sebumeter.® Five different facial sites were selected-forehead (mid glabella), nose (the tip), right and left cheek (the most prominent area of both zygomata and chin (the mental prominence). Results: Mild acne (Grade I) was seen in 22.5%, moderate acne (Grade II) in 42.5% and moderately severe acne (Grade III) in 27.5%.Of the 40 patients who completed 6 weeks of therapy, 90% showed a global improvement in their acne from baseline. About 19 patients (47.5%) showed excellent and another 15 (37.5%) showed a good improvement. Lesions showed poor response in only 4 patients (3%). Average sebum excretion rate of T- Zone at baseline was 91.34±43.26, whereas after 6-weeks treatment it was 82.68±40.50. Conclusion: Treatment with 0.1% Adapalenegel did not show significant decrease in MFSE, even though it significantly reduced acne lesions. This suggestive of other important factors playing vital role in comedogenesis.
Authors and Affiliations
Ajay Govindrao Ovhal, Jerajani H R, Dhurat R S
Keywords
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