Metabolic syndrome’s risk factor and relation with coronary artery disease
Journal Title: Medpulse International Journal of Medicine - Year 2017, Vol 4, Issue 3
Abstract
Background: Metabolic Syndrome (MS) represents a constellation of risk factors. Modified IDF definition for Asian Indian MS is any 3 out of five – abd obesity male 90 cm, female 80cm, fasting blood glucose100 mg, Hypertension 130 SBP, 85 DBP, High Triglyceride 150 mg/dl, Low HDL Male 40 mg /dl Female 50 mg/dl. Each risk factor of MS is pre therogenic and prothrombotic. Considering this interrelationship between MS risk factor and atherosclerosis, we planned this study to observe the impact of MS risk factor over coronary artery. Method: 76 Cases of Metabolic Syndrome (MS) fulfilling the criteria of MS, symptomatic for IHD and willing for coronary angiography were included in this study. Coronary angiography was done as per standard protocol. Coronary angiography finding were noted by two experienced cardiologist, who were blinded for symptomatology and MS risk factor. Observation and Results: The age distribution in angio proved CAD was in the range of 32-78 years, maximum cases were seen in 41-50 yrs. (37%). Male female ratio was 3.9:1. Thus male preponderance and CAD at early age group is noted in this study. Waist circumference in CAD group is 97.04 ± 6.57, while normal coronary artery group is 93.37 ± 6.61.In multivariate analysis abdominal obesity is statistically significant (or -9.72,95% c1(1.35-69.67),(p=0.024). Coronary artery disease was noted in 49 cases, 26 (53%) had hypertension, while 23 (47%) were normotensive. This difference between two group is not significant (p- 0.835). Impaired fasting blood sugar was noted in 53 (59.7%) MS cases. Out of 53, CAD was seen in 38 (71.7%) while 15 (29%) had normal coronaries. This finding is statistically significant (p-0.046). In multivariate analysis impaired fasting blood glucose between CAD and normal coronary group found significant (OR-1.02, 95% (1.00 – 1.04)) (P- 0.043). Mean TG level in CAD group is (161.16 ± 41.3), normal coronary group is (137.70 ± 32.27) (p-0.0072), this difference is statistically significant. The mean HDL Level is 36.99 ± 8.6 in CAD group while normal coronary art group is 39.52± 9.88, (p-0.805), this is statistically insignificant. CAD was noted in MS five risk factor 21/26 (80%), four risk factor 16/25 (64%), three risk factor 12/25 (48%).We found coronary artery disease in 14 cases of smoker while normal coronary artery in 2 smokers (p-0.030), this is statistically significant. Conclusion: Central Obesity, impaired fasting blood glucose and smoking found to be an independent risk factor in MS responsible CAD. Risk for CAD increases as increase in risk factor of MS.
Authors and Affiliations
Raut S G, Chavan M S, Deshpande M A, Washimkar S N
Keywords
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