Study of POP score, serum cholinesterase and serum creatine phosphokinase in organo phosphorus poisoning
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 1
Abstract
Background: Organophorous compounds are commonly used for suicide in developing country like India due to their easy availability.This study was undertaken to corelate Peradeniya organophosphorus scoring, serum CPK level and Plasma cholinesterase level at time of admission with ventilator requirement and mortality. Material and Methods: This was a retrospective study done at Government Medical College and S.S.G Civil hospital Vadodara , Gujarat. Over a period of two year 150 patients fulfilling inclusion criteria, were included and patients were categorized according to Peradeniya organophosphorus poisoning (POP) scale. Level of serum CPK, and plasma cholinesterase were measured on admission. Their relation in respect to ventilator requirement and mortality were assessed statistically using Chi Square test. Results: In study of 150 patients, maximum incidence is in 20-29 years of age group (34%). Males (77%) are more affected as compared to females (23%). Maximum cases were related to suicidal intent (86 %) followed by accidental exposure(14%). According to POP scale 24% cases had mild poisoning and 69% cases had moderate while 07% patient were severely poisoned. Correlation of POP score, Plasma Cholinesterase(PCh) level and serum CPK level with ventilator support requirements and mortality was determined stastically. Significant (p value <0.0001) correlation found between them except for PChE and ventilator support (p value<0.08). Conclusion: We recommends routine use of POP score at primary health care settings to classify OP patients according to their severity and timely refer them to higher center to reduce mortality. We also recommend S. CPK level to be used as routine biomarker of severity in OP patients along with PChE level to study its efficacy as a prognostic marker.
Authors and Affiliations
Jignesh F Vasava, Mahesh M Rathod, Poma Shah, Ajay S. Dabhi
Keywords
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- DOI 10.26611/1021915
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