Efficacy of adding intrathecal magnesium sulphate for lower limb surgeries in supine position under subarachnoid block with bupivacaine: A prospective randomized double-blind clinical trial
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background and objectives: Magnesium has antinociceptive effects in animal and human models of pain. In 1906, Haubold and Meltzer showed that intrathecal administration of Magnesium Sulphate produces spinal anaesthesia that includes profound motor and sensory blockade without any permanent untoward effects. In this prospective randomized double blind controlled study, we evaluated the effect of adding intrathecal Magnesium Sulphate to Bupivacaine in patients undergoing elective lower limb surgeries.Methods and Materials: 40 patients undergoing elective lower limb surgeries were randomized into one of the two groups with 20 patients in each group. Control group: Control group (N=20) received patients 0.5% 2.5cc (12.5mg) Inj.bupivacaine + 0.1cc normal saline.MgSO4 group: MgSO4 group (N=20) received 0.5% 2.5cc Inj.bupivacaine+0.1cc 50% (50mg) magnesium sulphate. Study drugs are administered by intrathecal route. Parameters like bloodpressure, pulse rate, Onset time and duration of Sensory block and motor block. Statistical Analysis: Data were analysed by using Student t test and Chi-square/ Fisher Exact tests. Results: There is a delay in the onset of sensory and motor blockade with the use magnesium sulphate group.
Authors and Affiliations
Soumya M V, Sridevi S
Keywords
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- EP ID EP616668
- DOI 10.26611/101510216
- Views 141
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