EFFICACY OF CARBOXYMETHYLCELLULOSE VS POLYETHYLENE GLYCOL ARTIFICIAL TEAR FORMULATION FOR DRY EYE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 31
Abstract
BACKGROUND Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Dry eye is one of the most common causes of ocular morbidity in patients presenting to an ophthalmology outpatient department. Artificial tears are aqueous solutions containing polymers that determine their viscosity, retention time and adhesion to the ocular surface. In mild-to-moderate cases, they are the mainstay of treatment. Artificial tears act by replenishing the deficient aqueous layer of the tear film and diluting the inflammatory cytokines. Hence, in this study we are comparing the efficacy of carboxymethylcellulose with polyethylene glycol eye drops through Schirmer’s test and Tear Break-Up time. MATERIALS AND METHODS A prospective evaluation of cases presenting with symptoms of dry eye from March 2015 to April 2017 was done in tertiary health care. Patients with dry eye were identified with the help of slit lamp examination, Schirmer’s test (ST) and Tear Break-Up Time (TBUT). One group was instilled with one drop of carboxymethylcellulose (CMC 0.5%), while the second group was instilled with one drop of polyethylene glycol (PEG 400/PG). Both groups were prescribed their respective eye drops at a dose of three times a day and ST and TBUT were performed on day 0, 7 and 30. RESULTS Overall, 100 patients were included in the study. Demographic data and baseline characteristics were comparable among the groups. Group 2 had significant improvement in mean change in TBUT (week 0– P = 0.001; week 1- P = 0.001; and week 4- P = 0.001), and in ST (week 0- P = 0.02; week 1- P = 0.04; and week 4- P = 0.03) compared to Group 1 at all follow-ups. CONCLUSION Polyethylene glycol is better tear substitute than carboxymethylcellulose in improving objective component of dry eye, while improvement in subjective component is same with PEG 400/ PG and CMC 0.5%.
Authors and Affiliations
Archana Vilas Manekar, Ruchita Pradeep Rathi, Neha Chandrashekar Yerawar
Keywords
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- EP ID EP541117
- DOI 10.14260/jemds/2018/795
- Views 60
- Downloads 0
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