Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats
Journal Title: Open Veterinary Journal - Year 2013, Vol 3, Issue 6
Abstract
Acetaminophen (APAP) administration results in hepatotoxicity and hematotoxicity in cats. The response to three different treatments against APAP poisoning was evaluated. Free glutathione (GSH) (200mg/kg), niosomal GSH (14 mg/kg) and free amino acids (180 mg/kg of N-acetylcysteine and 280 mg/kg of methionine) were administered to cats that were intoxicated with APAP (a single dose of 150 mg/kg, p.o.). Serum concentration of alanine aminotransferase (ALT) along with serum, liver and erythrocyte concentration of GSH and methemoglobin percentage were measured before and 4, 24 and 72 hours after APAP administration. Free GSH (200 mg/kg) and niosomal GSH (14 mg/kg) were effective in reducing hepatotoxicity and hematotoxicity in cats intoxicated with a dose of 150 mg/kg APAP. We conclude that both types of treatments can protect the liver and haemoglobin against oxidative stress in APAP intoxicated cats. Furthermore, our results showed that treatment with niosomal GSH represents an effective therapeutic approach for APAP poisoning.
Authors and Affiliations
L. A. Denzoin Vulcano| Department of Physiopathology, Faculty of Veterinary Science, UNCPBA, Campus Universitario, Paraje Arroyo Seco. Tandil, 7000, Argentina, O. Confalonieri| Department of Clinic, Faculty of Veterinary Science, UNCPBA, Campus Universitario, Paraje Arroyo Seco. Tandil, 7000, Argentina, R. Franci| Department of Clinic, Faculty of Veterinary Science, UNCPBA, Campus Universitario, Paraje Arroyo Seco. Tandil, 7000, Argentina, M. O. Tapia| Department of Physiopathology, Faculty of Veterinary Science, UNCPBA, Campus Universitario, Paraje Arroyo Seco. Tandil, 7000, Argentina, A. L. Soraci| Department of Physiopathology, Faculty of Veterinary Science, UNCPBA, Campus Universitario, Paraje Arroyo Seco. Tandil, 7000, Argentina
Keywords
Related Articles
- EP ID EP9281
- DOI -
- Views 434
- Downloads 35
Lateral patellar luxation in nine small breed dogs
The objective of this paper was to describe the clinical features, the management and the outcome of nine small breed dogs affected with lateral patella luxation referred during the period between January 2010 and Decem...
Tsetse fly saliva: Could it be useful in fly infection when feeding in chronically aparasitemic mammalian hosts
Sleeping sickness and nagana are two important diseases cuased by African trypanosomes in humans and animals respectively, in tropical african countries. A number of trypanosome species are implicated in these diseases,...
Castration of dromedary camel through prescrotal midline incision
A total of 165 camels of different ages were castrated through a small, prescrotal midline incision between January, 2010 and December, 2011. The incision was closed with one interrupted, horizontal mattress suture usin...
Collection, analysis and cryopreservation of semen from Malayan gaur (Bos gaurus hubbacki): A preliminary study
The Malayan gaur (Bos gaurus hubbacki) or Seladang is classified as vulnerable by the International Union for Conservation of Nature and Natural Resources (IUCN). The Malayan gaur is mainly distributed in the tropical...
First report of blood parasites in fishes from Kashmir and their effect on the haematological profile
Cyprinus carpio communis Linnaeus, Carassius carassius Linnaeus, Schizothorax curvifrons Heckel and Triplophysa marmorata species of fishes were captured from Anchar Lake and river Jhelum of Kashmir Himalaya for hemato...