Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results
Journal Title: Open Veterinary Journal - Year 2017, Vol 7, Issue 4
Abstract
This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-yearold cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat’s clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.
Authors and Affiliations
Roberta Troia| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy, Chiara Agnoli| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy, Federico Fracassi| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy, Giuliano Bettini| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy, Alessandra Sfacteria| Department of Veterinary Sciences, University of Messina, Italy, Luciano Pisoni| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy, Francesco Dondi| Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy
Keywords
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- EP ID EP9444
- DOI http://dx.doi.org/10.4314/ovj.v7i4.1
- Views 412
- Downloads 39
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