Efficacy of fundus photocoagulation combined with triamcinolone acetonide on diabetic retinopathy
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11
Abstract
AIM: To observe the efficacy of fundus photocoagulation combined with triamcinolone acetonide(TA)in the treatment of diabetic retinopathy(DR). <p>METHODS: The clinical data of 94 patients(112 eyes)in our hospital from September 2016 to September 2017 were analyzed retrospectively. According to the treatment regimen, the patients were divided into fundus photocoagulation with TA group(study group, 54 cases 64 eyes)and fundus photocoagulation group(control group, 40 cases 48 eyes). The treatment conditions \〖best corrected visual acuity(BCVA), macular retinal thickness\〗 were monitored before treatment(T1)and after 7d, 1, 3 and 6mo of treatment(T2, T3, T4, T5), and the efficacy was assessed at T5, and the improvement times of clinical manifestations(fundus hemorrhage, exudation, retinal edema)were recorded, and the serological markers \〖intercellular adhesion molecule(ICAM-1)and vascular endothelial growth factor(VEGF)\〗 were measured at T1 and T5. <p>RESULTS: At T1 to T5, there were statistically significant differences in the between-group effects, time-point effects and interaction effects of between-group and time-point of BCVA and macular retinal thickness(<i>P</i><0.05). At T2 to T5, the BCVA was improved in the two groups with time while the macular retinal thickness was decreased with time(<i>P</i><0.05). The efficacy in study group was better than that in control group, and the improvement times of fundus hemorrhage, exudation and retinal edema were less than those in control group(<i>P</i><0.05). At T5, the serum levels of ICAM-1 and VEGF in the two groups were lower than those at T1, and the levels were lower in study group than those in control group(<i>P</i><0.05). <p>CONCLUSION: Fundus photocoagulation combined with TA can effectively improve the visual acuity and retinal edema in patients with DR, and it has significant efficacy, and it can help promote the recovery of clinical symptoms, reduce the vascular endothelial injury, and inhibit the neovascularization.
Authors and Affiliations
En-Xian Zhao
Keywords
Related Articles
- EP ID EP519481
- DOI 10.3980/j.issn.1672-5123.2018.11.04
- Views 123
- Downloads 0
Research progress of visual plasticity related factors and environment effecting amblyopia treatment
Amblyopia is the most common cause of poor monocular vision in children. The prevalence of world population is 1%-5% and in China is about 2%-4% with yearly growth trend. Amblyopia mainly occurs in the sensitive period o...
Clinical efficacy of disinhibition and visual function training in children patients with anisometropic amblyopia
AIM:To evaluate the clinical efficacy of treatment <i>via</i> disinhibition and visual function training in children patients with anisometropic amblyopia. <p>METHODS: Eighty-three children patients with anisometropic am...
Research progress in the treatment of retinoblastoma
Retinoblastoma(RB)is the most common intraocular malignant tumor in infants, the pathogenesis of which, is related to gene mutations. In order to improve the survival rate and eye-protection rate of RB patients, the ther...
Comparison of corneal curvature and astigmatism measurements with four kinds of instruments before cataract surgery
AIM: To compare corneal curvature and astigmatism values identified with OPD-Scan Ⅲ, IOL Master, Pentacam and KR-8900 in cataract patients and to evaluate the consistencies and differences. <p>METHODS: In this prospectiv...
Correlation analysis of ocular biological parameters of cataract eyes with high myopia before and after cataract surgery
AIM: To analyze the biometric parameters before and after cataract surgeries of the cataract eyes with high myopia, and to provide reference for the calculation of intraocular lens diopter for cataract eyes with high myo...