Efficacy of Injection Histoglob in Treatment of Chronic Urticaria-A Prospective Study.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Objectives: To assess the efficacy of injection Histoglob in treatment of chronic urticaria. Materials and methods: Thirty five patients with chronic urticaria(CU) were enrolled into this prospective clinical study. Injection histaglob was given as a weekly dose of 1ml subcutaneously for 8 consecutive weeks.Tab Levocetrizine 5mg was permitted as and required not exceeding the recommended permitted dose. The efficacy of the drug was assessed using urticaria activity score(UAS) which has a maximum score of 6/day. The assessment was done at every weekly visit and at 24th week which was the final assessment. Results: Out of thirty five patients enrolled ,twenty six patients had completed the entire schedule of dosage of 8 weeks and final follow-up at 24th week. The mean basal UAS was 5.1 at the time of enrollment to the study and it reduced to 1.01 with a reduction of 80.2%.At the end of 24 weeks 17 patients out of 35 (48.5%) attained complete remission .There was also a remarkable drop in the usage of antihistaminics. No adverse effects were observed in the study group. Conclusion: Histagloblin was found to be effective in producing long-term remission and it reduced the antihistamine requirement as well. Thus, it can serve as an effective alternative to existing treatment modalities.
Authors and Affiliations
Dr. Surya mangadevi Thota
Keywords
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- EP ID EP555710
- DOI 10.9790/0853-1803085762.
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