Efficacy of intravitreal Conbercept combined with retinal photocoagulation in the treatment of DR complicated with DME
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 5
Abstract
AIM: To evaluate the efficacy of intravitreal Conbercept combined with retinal photocoagulation in treating diabetic retinopathy(DR)with diabetic macular edema(DME). <p>METHODS: Prospective case study. Totally 48 patients(80 eyes)diagnosed as DR with DME randomized to combined group and laser group. Among them, there were 4 patients with 5 eyes in the moderate stage of non-proliferative DR(NPDR), 38 patients with 65 eyes in the severe stage of NPDR, and 6 cases with 10 eyes in the stage of proliferative DR(PDR). Intravitreal conbercept(IVC)and pan retinal photocoagulation(PRP)were performed in the combined group; the macular grid pattern laser photocoagulation and PRP were performed in the laser group. Best corrected visual acuity(BCVA),central macular thickness(CMT)and laser energy were tested at baseline and repeated at 1wk, 1, 3, 6, and 12mo after PRP. <p>RESULTS: Repeated measures showed an effect of treatment in combined group. Combined group induced increased BCVA at 1wk, 1 and 3mo after PRP, and remained stable in 6 and 12mo after PRP. Laser group induced increased BCVA at 1 and 3mo after PRP, and remained stable in 1wk, 6 and 12mo after PRP. Combined group induced decreased CMT at 1wk, 1 and 3mo post PRP, and remained stable in 6 and 12mo after PRP. Laser group induced decreased CMT at 1 and 3mo after PRP, and remained stable in 1wk, 6 and 12mo post PRP. There was no laser spot fusion was observed in the two groups during the follow-up. Laser energy in the combined group was lower than that in the laser group. No complications were observed during the follow-up.<p>CONCLUSION: IVC and retinal photocoagulation significantly improves visual and anatomic outcomes in patients with DR complicated with DME. Long-term efficacy remains to be seen.
Authors and Affiliations
Li - Hua Hou
Keywords
Related Articles
- EP ID EP656694
- DOI 10.3980/j.issn.1672-5123.2018.5.41
- Views 131
- Downloads 0
Effect of ILK SiRNA on the proliferation and apoptosis of human Tenon fibroblasts induced by transforming growth factor-β<sub>2</sub>
AIM: To investigate the role of small interference RNA interference targeted Integrin-linked kinase(ILK SiRNA)on the proliferation and apoptosis of human Tenon fibroblasts(HTFs)induced by transforming growth factor-β<sub...
Comparison between time-domain and spectral-domain OCT in the detection of retinal nerve fiber layer defects in glaucoma patients
AIM: To compare the use of the instruments' built-in normative databases, the sensitivities of time-domain optical coherence tomography(Stratus OCT)and spectral-domain OCT(Spectralis OCT)in the detection of retinal nerve...
Effect of built-in type OASIS iris expander in phacoemulsification surgery for cataract with small pupil
AIM: To observe the effect of built-in type OASIS iris expander in phacoemulsification surgery for cataract with small pupil. <p>METHODS: Totally 44 cataract patients with small pupil were treated in our hospital from Ja...
Efficacy of macular focal/grid laser photocoagulation with Ranibizumab for diabetic macular edema
AIM: To investigate the effect of macular focal/grid laser photocoagulation with Ranibizumab on the treatment of diabetic macular edema(DME). <p>METHODS: Totally 70 patients(99 eyes)with DME treated in our hospital from...
Risk factors of secondary intraocular hypertension after silicone oil tamponade
Silicone oil, as a temporary vitreous substitute, has been widely applied to the treatment of various complex vitreoretinal disease. However, silicone oil tamponade also causes a variety of postoperative complications, t...