Efficacy of low dose intrathecal clonidine as an adjuvant to 0.5% hyperbaric bupivacaine for spinal anaesthesia
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 1
Abstract
Background and Aims: Nowadays intrathecally various drugs adjvents are being used for the purpose of enhancing spinal action of local anaesthetic agents hence postoperative analgesia. The aim of this study was to observe the efficacy of low dose of Clonidine as an adjuvent to 0.5 % hyperbaric Bupivacaine for spinal anaesthesia. Methods: In this study total100 patients of age between 20 years and 50 years of either gender belonging to ASA Class I or Class II posted for elective lower abdominal and lower limb surgeries were selected for the study. The study population was randomly divided into 2 groups with 50 patients in each group (N=50). All cases were randomly allocated to two groups in double blind manner. Group B(Control group):received 2.5ml (12.5mg) of 0.5% hyperbaric Bupivacaine intrathecally. Group BC(Study group): received 2.5ml (12.5mg) of 0.5% hyperbaric Bupivacaine +1µg/kg of Inj. Clonidine intrathecally. Onset of sensory block noted and time to achieve highest level was recorded. Duration of sensory block was assessed by time to regression of analgesia to S2 segment. Degree of analgesia was assessed by scale as 1-4 (excellent to poor), degree of motor block assessed by Bromage scale Vitals parameters like Pulse, BP, RR, SpO2, sedation score and complications like PONV, sedation were noted. Postoperative pain was assessed using Visual Analog Scale (VAS) Score.Inj. Diclofenac 75 mg given intramuscularly at VAS 5 or as a rescue analgesic when demanded by patient. Total duration of analgesia was calculated from time of intrathecal injection to rescue analgesic given. Results: Results were analysed using Standard t test. Duration of effective analgesia was 130.4 ±13.24 Min. in Group B and 307.4 ± 41.93 Min. in Group BC (p value<o.oo1). Sedation and adverse effects were comparable in between two groups. Conclusion: To conclude use of clonidine with bupivacaine effectively increases the duration of anaesthesia hence postoperative analgesia and also provides sedation.
Authors and Affiliations
Maruti Pawar, Shriganesh Kamat
Keywords
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- EP ID EP440252
- DOI 10.26611/1015916
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