Efficacy Of Lyophilized Inactivated Rabies Vaccine
Journal Title: Journal of Applied Veterinary Sciences - Year 2020, Vol 5, Issue 4
Abstract
An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms. Inactivated rabies vaccine prepared from BHK21 infected cell culture in the two forms revealed that its immunogenicity was completely preserved on lyophilization. The two vaccine formulae were found to be free from foreign contaminants, safe in both inoculated mice and puppies and potent inducing high levels of specific rabies antibodies in vaccinated puppies. Such antibodies were increased gradually from the first-week post-vaccination to the same extent in the blood of immunized puppies with the lyophilized vaccine as in that of puppies immunized with liquid vaccine. These results confirmed the claim that inactivated rabies vaccines could be lyophilized with retention of potency. Considering the possible value of a stable, freeze-dried rabies vaccine that could be stored and transported with ease, it was considered desirable to confirm the above findings.
Authors and Affiliations
Omaima A. E. Elshamandy and Heba M. G. Abd El-Aziz2
Keywords
Related Articles
- EP ID EP689579
- DOI 10.21608/JAVS.2020.120348
- Views 179
- Downloads 0
Trials For Preparation And Evaluation Of Inactivated Tissue Culture Newcastle Disease Vaccine From Recent Isolate
The present study was undertaken to develop of BHK-21 cell adapted inactivated vaccine of Newcastle disease virus (NDVgenotype VII) from the field isolate from broiler chicken in Egypt during 2015-2016. The isolates of E...
Prevalence and Antibiogram of Escherichia coli isolates recovered from bovine milk
Antimicrobial resistance is considered a major threat facing humanity. It doesn’t only affect public health, but also causes great losses in the dairy industry. Mastitis is a major threat to the dairy industry. The aim o...
Plumage Color Influence on Immune Response and Severity of Fowlpox in The Progeny of Inbred Isa White Chickens
There is limited information regarding chicken's inter and intra-breed resistance to the fowlpox virus (FWPV). Incidentally, it was observed during a natural fowlpox outbreak in a flock of inbred Isa White chickens havin...
Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
The aim of the present study was to investigate the potential antioxidant and Hepatoprotective activities of tranilast against TAA-induced liver fibrosis in rats. Methods: Liver fibrosis was induced in rats by intraperit...
The Fertility Outcomes of Egyptian Buffalo Cows after Ovsynch and Presynch-Ovsynch Protocols
The present study aimed to compare the reproductive outcomes after the blind application of the standard Ovsynch and Presynch Ovsynch protocols on Egyptian Buffaloes (Bubalus bubalis) during the breeding season. Fifty mu...